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HLA-A*31 as a marker of genetic susceptibility to sepsis

OBJECTIVE: The HLA haplotype has been associated with many autoimmune diseases, but no associations have been described in sepsis. This study aims to investigate the HLA system as a possible marker of genetic sepsis susceptibility. METHODS: This is a prospective cohort study including patients admit...

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Detalles Bibliográficos
Autores principales: da Silva, Fabiano Pinheiro, Preuhs Filho, Germano, Finger, Eduardo, Barbeiro, Hermes Vieira, Zampieri, Fernando Godinho, Goulart, Alessandra Carvalho, Torggler Filho, Francisco, Panajotopoulos, Nicolas, Velasco, Irineu Tadeu, Kalil, Jorge, de Souza, Heraldo Possolo, da Cruz Neto, Luiz Monteiro, Rodrigues, Hélcio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Medicina intensiva 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031872/
https://www.ncbi.nlm.nih.gov/pubmed/24553509
http://dx.doi.org/10.5935/0103-507X.20130049
Descripción
Sumario:OBJECTIVE: The HLA haplotype has been associated with many autoimmune diseases, but no associations have been described in sepsis. This study aims to investigate the HLA system as a possible marker of genetic sepsis susceptibility. METHODS: This is a prospective cohort study including patients admitted to an intensive care unit and healthy controls from a list of renal transplant donors. Patients with less 18 years of age; pregnant or HIV positive patients; those with metastatic malignancies or receiving chemotherapy; or with advanced liver disease; or with end-of-life conditions were excluded. The DNA was extracted from the whole blood and HLA haplotypes determined using MiliPlex(®) technology. RESULTS: From October 2010 to October 2012, 1,121 patients were included (1,078 kidney donors, 20 patients admitted with severe sepsis and 23 with septic shock). HLA-A*31 positive subjects had increased risk of developing sepsis (OR 2.36, 95%CI 1.26-5.35). Considering a p value <0.01, no other significant association was identified. CONCLUSION: HLA-A*31 expression is associated to risk of developing sepsis.