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Anti-salivary gland protein 1 antibodies in two patients with Sjogren’s syndrome: two case reports

INTRODUCTION: Current diagnostic criteria for Sjogren’s syndrome developed by the American College of Rheumatology include the presence of antinuclear antibodies, rheumatoid factor, anti-Ro or anti-La autoantibodies. The purpose of this report is to describe two patients with biopsy-proven Sjogren’s...

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Autores principales: Vishwanath, Sahana, Shen, Long, Suresh, Lakshmanan, Ambrus, Julian L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031912/
https://www.ncbi.nlm.nih.gov/pubmed/24885364
http://dx.doi.org/10.1186/1752-1947-8-145
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author Vishwanath, Sahana
Shen, Long
Suresh, Lakshmanan
Ambrus, Julian L
author_facet Vishwanath, Sahana
Shen, Long
Suresh, Lakshmanan
Ambrus, Julian L
author_sort Vishwanath, Sahana
collection PubMed
description INTRODUCTION: Current diagnostic criteria for Sjogren’s syndrome developed by the American College of Rheumatology include the presence of antinuclear antibodies, rheumatoid factor, anti-Ro or anti-La autoantibodies. The purpose of this report is to describe two patients with biopsy-proven Sjogren’s syndrome lacking these autoantibodies but identified by antibodies to salivary gland protein 1. Diagnosis was delayed until salivary gland tumors developed in these patients because of the lack of the classic autoantibodies. This report emphasizes the existence of patients with primary Sjogren’s syndrome who lack autoantibodies anti-Ro or anti-La and may therefore be misdiagnosed. Antibodies to salivary gland protein 1 identify some of these patients. CASE PRESENTATION: Two patients are described and were seen in the autoimmune disease clinics of the State University of New York (SUNY) at the Buffalo School of Medicine. In both patients, chronic dry mouth and dry eye had been dismissed as idiopathic because test results for autoantibodies anti-Ro and anti-La were negative. Both patients had swelling of major salivary glands that prompted biopsies. Biopsies of major salivary glands from both cases demonstrated salivary gland tumors and existence of inflammation consistent with Sjogren’s syndrome. Serologic testing revealed antibodies to salivary gland protein 1. CONCLUSIONS: Patients presenting with classic clinical symptoms of dry mouth and eyes do not always show the current serologic markers of Sjogren’s syndrome, anti-Ro and anti-La. In these cases, investigation for antibodies to salivary gland protein 1 is of importance to make the diagnosis of Sjogren’s syndrome. Early diagnosis of Sjogren’s syndrome is necessary for improved management as well as for vigilance regarding potential complications, such as salivary gland tumors as were seen in the described cases.
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spelling pubmed-40319122014-05-24 Anti-salivary gland protein 1 antibodies in two patients with Sjogren’s syndrome: two case reports Vishwanath, Sahana Shen, Long Suresh, Lakshmanan Ambrus, Julian L J Med Case Rep Case Report INTRODUCTION: Current diagnostic criteria for Sjogren’s syndrome developed by the American College of Rheumatology include the presence of antinuclear antibodies, rheumatoid factor, anti-Ro or anti-La autoantibodies. The purpose of this report is to describe two patients with biopsy-proven Sjogren’s syndrome lacking these autoantibodies but identified by antibodies to salivary gland protein 1. Diagnosis was delayed until salivary gland tumors developed in these patients because of the lack of the classic autoantibodies. This report emphasizes the existence of patients with primary Sjogren’s syndrome who lack autoantibodies anti-Ro or anti-La and may therefore be misdiagnosed. Antibodies to salivary gland protein 1 identify some of these patients. CASE PRESENTATION: Two patients are described and were seen in the autoimmune disease clinics of the State University of New York (SUNY) at the Buffalo School of Medicine. In both patients, chronic dry mouth and dry eye had been dismissed as idiopathic because test results for autoantibodies anti-Ro and anti-La were negative. Both patients had swelling of major salivary glands that prompted biopsies. Biopsies of major salivary glands from both cases demonstrated salivary gland tumors and existence of inflammation consistent with Sjogren’s syndrome. Serologic testing revealed antibodies to salivary gland protein 1. CONCLUSIONS: Patients presenting with classic clinical symptoms of dry mouth and eyes do not always show the current serologic markers of Sjogren’s syndrome, anti-Ro and anti-La. In these cases, investigation for antibodies to salivary gland protein 1 is of importance to make the diagnosis of Sjogren’s syndrome. Early diagnosis of Sjogren’s syndrome is necessary for improved management as well as for vigilance regarding potential complications, such as salivary gland tumors as were seen in the described cases. BioMed Central 2014-05-11 /pmc/articles/PMC4031912/ /pubmed/24885364 http://dx.doi.org/10.1186/1752-1947-8-145 Text en Copyright © 2014 Vishwanath et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Vishwanath, Sahana
Shen, Long
Suresh, Lakshmanan
Ambrus, Julian L
Anti-salivary gland protein 1 antibodies in two patients with Sjogren’s syndrome: two case reports
title Anti-salivary gland protein 1 antibodies in two patients with Sjogren’s syndrome: two case reports
title_full Anti-salivary gland protein 1 antibodies in two patients with Sjogren’s syndrome: two case reports
title_fullStr Anti-salivary gland protein 1 antibodies in two patients with Sjogren’s syndrome: two case reports
title_full_unstemmed Anti-salivary gland protein 1 antibodies in two patients with Sjogren’s syndrome: two case reports
title_short Anti-salivary gland protein 1 antibodies in two patients with Sjogren’s syndrome: two case reports
title_sort anti-salivary gland protein 1 antibodies in two patients with sjogren’s syndrome: two case reports
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031912/
https://www.ncbi.nlm.nih.gov/pubmed/24885364
http://dx.doi.org/10.1186/1752-1947-8-145
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