Cargando…

Correcting for Differential Transcript Coverage Reveals a Strong Relationship between Alternative Splicing and Organism Complexity

What at the genomic level underlies organism complexity? Although several genomic features have been associated with organism complexity, in the case of alternative splicing, which has long been proposed to explain the variation in complexity, no such link has been established. Here, we analyzed ove...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Lu, Bush, Stephen J., Tovar-Corona, Jaime M., Castillo-Morales, Atahualpa, Urrutia, Araxi O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Discoveries
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032128/ https://www.ncbi.nlm.nih.gov/pubmed/24682283 http://dx.doi.org/10.1093/molbev/msu083

Ejemplares similares

Alternative Splice in Alternative Lice
por: Tovar-Corona, Jaime M., et al.
Publicado: (2015)

Presence–Absence Variation in A. thaliana Is Primarily Associated with Genomic Signatures Consistent with Relaxed Selective Constraints
por: Bush, Stephen J., et al.
Publicado: (2014)

Genes That Escape X-Inactivation in Humans Have High Intraspecific Variability in Expression, Are Associated with Mental Impairment but Are Not Slow Evolving
por: Zhang, Yuchao, et al.
Publicado: (2013)

Inferring Adaptive Codon Preference to Understand Sources of Selection Shaping Codon Usage Bias
por: de Oliveira, Janaina Lima, et al.
Publicado: (2021)

Alternative Splicing: A Potential Source of Functional Innovation in the Eukaryotic Genome
por: Chen, Lu, et al.
Publicado: (2012)

Increased levels of noisy splicing in cancers, but not for oncogene-derived transcripts
por: Chen, Lu, et al.
Publicado: (2011)

Evidence for Strong Mutation Bias toward, and Selection against, U Content in SARS-CoV-2: Implications for Vaccine Design
por: Rice, Alan M, et al.
Publicado: (2020)

Regulation of Splicing Factors by Alternative Splicing and NMD Is Conserved between Kingdoms Yet Evolutionarily Flexible
por: Lareau, Liana F., et al.
Publicado: (2015)

Sex-Specific Selection Drives the Evolution of Alternative Splicing in Birds
por: Rogers, Thea F, et al.
Publicado: (2020)

Increased brain size in mammals is associated with size variations in gene families with cell signalling, chemotaxis and immune-related functions
por: Castillo-Morales, Atahualpa, et al.
Publicado: (2014)

Modular reorganization of the global network of gene regulatory interactions during perinatal human brain development
por: Monzón-Sandoval, Jimena, et al.
Publicado: (2016)

Evidence for Deep Phylogenetic Conservation of Exonic Splice-Related Constraints: Splice-Related Skews at Exonic Ends in the Brown Alga Ectocarpus Are Common and Resemble Those Seen in Humans
por: Wu, XianMing, et al.
Publicado: (2013)

The Transcriptional and Splicing Changes Caused by Hybridization Can Be Globally Recovered by Genome Doubling during Allopolyploidization
por: Qin, Jinxia, et al.
Publicado: (2021)

Protein Amino Acid Composition: A Genomic Signature of Encephalization in Mammals
por: Gutierrez, Humberto, et al.
Publicado: (2011)

MeDAS: a Metazoan Developmental Alternative Splicing database
por: Li, Zhidan, et al.
Publicado: (2020)

Neocortex expansion is linked to size variations in gene families with chemotaxis, cell–cell signalling and immune response functions in mammals
por: Castillo-Morales, Atahualpa, et al.
Publicado: (2016)

Purifying Selection on Exonic Splice Enhancers in Intronless Genes
por: Savisaar, Rosina, et al.
Publicado: (2016)

Population Bottlenecks Strongly Affect the Evolutionary Dynamics of Antibiotic Persistence
por: Windels, Etthel M, et al.
Publicado: (2021)

Strong Positive Selection in Aedes aegypti and the Rapid Evolution of Insecticide Resistance
por: Love, R Rebecca, et al.
Publicado: (2023)

Population Bottlenecks Strongly Influence the Evolutionary Trajectory to Fluoroquinolone Resistance in Escherichia coli
por: Garoff, Linnéa, et al.
Publicado: (2020)

Transcription Factors Drive Opposite Relationships between Gene Age and Tissue Specificity in Male and Female Drosophila Gonads
por: Witt, Evan, et al.
Publicado: (2021)

Recurrent Reverse Evolution Maintains Polymorphism after Strong Bottlenecks in Commensal Gut Bacteria
por: Sousa, Ana, et al.
Publicado: (2017)

Strong, Recent Selective Sweeps Reshape Genetic Diversity in Freshwater Bivalve Megalonaias nervosa
por: Rogers, Rebekah L, et al.
Publicado: (2023)

Determinants of the Usage of Splice-Associated cis-Motifs Predict the Distribution of Human Pathogenic SNPs
por: Wu, XianMing, et al.
Publicado: (2016)

Alternative splicing and co-option of transposable elements: the case of TMPO/LAP2α and ZNF451 in mammals
por: Abascal, Federico, et al.
Publicado: (2015)

A High-Coverage Yersinia pestis Genome from a Sixth-Century Justinianic Plague Victim
por: Feldman, Michal, et al.
Publicado: (2016)

Rates of Vaccine Evolution Show Strong Effects of Latency: Implications for Varicella Zoster Virus Epidemiology
por: Weinert, Lucy A., et al.
Publicado: (2015)

Strong Purifying Selection in Haploid Tissue–Specific Genes of Scots Pine Supports the Masking Theory
por: Cervantes, Sandra, et al.
Publicado: (2023)

Strong Constraint on Human Genes Escaping X-Inactivation Is Modulated by their Expression Level and Breadth in Both Sexes
por: Slavney, Andrea, et al.
Publicado: (2016)

A Two-Locus System with Strong Epistasis Underlies Rapid Parasite-Mediated Evolution of Host Resistance
por: Ameline, Camille, et al.
Publicado: (2020)

Remarkably Low KIR and HLA Diversity in Amerindians Reveals Signatures of Strong Purifying Selection Shaping the Centromeric KIR Region
por: de Brito Vargas, Luciana, et al.
Publicado: (2021)

Genes that Escape X-Inactivation in Humans Have High Intraspecific Variability in Expression, Are Associated with Mental Impairment but Are Not Slow Evolving
por: Zhang, Yuchao, et al.
Publicado: (2016)

Purifying Selection on Splice-Related Motifs, Not Expression Level nor RNA Folding, Explains Nearly All Constraint on Human lincRNAs
por: Schüler, Andreas, et al.
Publicado: (2014)

An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors
por: Jin, Jinpu, et al.
Publicado: (2015)

Alternative Evolutionary Paths to Bacterial Antibiotic Resistance Cause Distinct Collateral Effects
por: Barbosa, Camilo, et al.
Publicado: (2017)

Human Lineage-Specific Transcriptional Regulation through GA-Binding Protein Transcription Factor Alpha (GABPa)
por: Perdomo-Sabogal, Alvaro, et al.
Publicado: (2016)

Plastic Rewiring of Sef1 Transcriptional Networks and the Potential of Nonfunctional Transcription Factor Binding in Facilitating Adaptive Evolution
por: Hsu, Po-Chen, et al.
Publicado: (2021)

Mitogenomes Reveal Alternative Initiation Codons and Lineage-Specific Gene Order Conservation in Echinoderms
por: Quek, Zheng Bin Randolph, et al.
Publicado: (2020)

Why Selection Might Be Stronger When Populations Are Small: Intron Size and Density Predict within and between-Species Usage of Exonic Splice Associated cis-Motifs
por: Wu, XianMing, et al.
Publicado: (2015)

Genome-Wide Transcript Profiling Reveals the Coevolution of Plastid Gene Sequences and Transcript Processing Pathways in the Fucoxanthin Dinoflagellate Karlodinium veneficum
por: Richardson, Elisabeth, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_j73rpfv9eupcblsnsburqvjoq7