Cargando…

Development of a Folate Receptor (FR)-Targeted Indenoisoquinoline Using a pH-Sensitive N-Ethoxybenzylimidazole (NEBI) Bifunctional Cross-Linker

[Image: see text] This Communication describes the synthesis and evaluation of a folate-conjugated drug delivery system (DDS) that incorporates an acid-sensitive N-ethoxybenzylimidazole (NEBI) bifunctional linker and a novel imidazole-containing indenoisoquinoline. Indenoisoquinolines are a class of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Yuchen, Yang, Jerry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032194/ https://www.ncbi.nlm.nih.gov/pubmed/24758386 http://dx.doi.org/10.1021/bc500146p

Ejemplares similares

Binding of an Indenoisoquinoline to the Topoisomerase-DNA Complex Induces Reduction of Linker Mobility and Strengthening of Protein-DNA Interaction
por: Mancini, Giordano, et al.
Publicado: (2012)

Bioorthogonal, Bifunctional Linker for Engineering Synthetic Glycoproteins
por: McBerney, Ryan, et al.
Publicado: (2022)

Novel clinical indenoisoquinoline topoisomerase I inhibitors: a twist around the camptothecins
por: Pommier, Yves, et al.
Publicado: (2018)

Solvent Dependency of the UV-Vis Spectrum of Indenoisoquinolines: Role of Keto-Oxygens as Polarity Interaction Probes
por: Coletta, Andrea, et al.
Publicado: (2013)

Synthesis and Biological Activity of a New Indenoisoquinoline Copper Derivative as a Topoisomerase I Inhibitor
por: Molinaro, Caroline, et al.
Publicado: (2023)

Serum folate receptor α (sFR) in ovarian cancer diagnosis and surveillance
por: Farran, Batoul, et al.
Publicado: (2019)

Facile synthesis of folate-conjugated magnetic/fluorescent bifunctional microspheres
por: Shen, Mao, et al.
Publicado: (2014)

Folate and Borneol Modified Bifunctional Nanoparticles for Enhanced Oral Absorption
por: Yang, Yifan, et al.
Publicado: (2018)

Dynamic pH responsivity of triazole-based self-immolative linkers
por: Roberts, Derrick A., et al.
Publicado: (2020)

A Self-Immolative Linker for the pH-Responsive Release of Amides
por: Petrini, Agnese, et al.
Publicado: (2023)

Bifunctional Inhibitors of Influenza Virus Neuraminidase: Molecular Design of a Sulfonamide Linker
por: Evteev, Sergei, et al.
Publicado: (2021)

Enhancing proline-rich antimicrobial peptide action by homodimerization: influence of bifunctional linker
por: Li, Wenyi, et al.
Publicado: (2022)

The Chemical Scaffold of Theranostic Radiopharmaceuticals: Radionuclide, Bifunctional Chelator, and Pharmacokinetics Modifying Linker
por: Holik, Holis Abdul, et al.
Publicado: (2022)

Identification of folate receptor α (FRα) binding oligopeptides and their evaluation for targeted virotherapy applications
por: Hulin-Curtis, Sarah L., et al.
Publicado: (2020)

Metabolic bifunctionality of Rv0812 couples folate and peptidoglycan biosynthesis in Mycobacterium tuberculosis
por: Black, Katherine A., et al.
Publicado: (2021)

The role of folate receptor alpha (FRα) in the response of malignant pleural mesothelioma to pemetrexed-containing chemotherapy
por: Nutt, J E, et al.
Publicado: (2010)

Design, Synthesis, and Biological Evaluation of O-2-Modified Indenoisoquinolines as Dual Topoisomerase I–Tyrosyl-DNA Phosphodiesterase I Inhibitors
por: Lv, Peng-Cheng, et al.
Publicado: (2014)

Effects of parental folate deficiency on the folate content, global DNA methylation, and expressions of FRα, IGF-2 and IGF-1R in the postnatal rat liver
por: Mejos, Karen Kay, et al.
Publicado: (2013)

Conversion of the Sensor Kinase DcuS to the Fumarate Sensitive State by Interaction of the Bifunctional Transporter DctA at the TM2/PAS(C)-Linker Region
por: Stopp, Marius, et al.
Publicado: (2021)

A Novel Copper(II) Indenoisoquinoline Complex Inhibits Topoisomerase I, Induces G2 Phase Arrest, and Autophagy in Three Adenocarcinomas
por: Molinaro, Caroline, et al.
Publicado: (2022)

A universal strategy of glyconanoparticle preparation using a bifunctional linker for lectin sensing and cell imaging
por: Sha, Qiuyue, et al.
Publicado: (2022)

Decay of the $N=126, ^{213}$Fr nucleus
por: Pragati,, et al.
Publicado: (2016)

Effect of the Addition of a Cross-Linker and the Water pH on the Physical Properties of Films of pH-Responsive Polymer Particles at Air/Water Interfaces
por: Azakami, Yuka, et al.
Publicado: (2017)

Synthesis of a pH-Sensitive Nitrilotriacetic Linker to Peptide Transduction Domains To Enable Intracellular Delivery of Histidine Imidazole Ring-Containing Macromolecules
por: June, Ronald K., et al.
Publicado: (2010)

Preparation and performance of a pH-sensitive cisplatin-loaded magnetic nanomedicine that targets tumor cells via folate receptor mediation
por: CHEN, SHUAI-JUN, et al.
Publicado: (2016)

Folate-coated, long-circulating and pH-sensitive liposomes enhance doxorubicin antitumor effect in a breast cancer animal model
por: de Oliveira Silva, Juliana, et al.
Publicado: (2019)

The Role of the N-D1 Linker of the N-Ethylmaleimide-Sensitive Factor in the SNARE Disassembly
por: Liu, Cui-Cui, et al.
Publicado: (2013)

Switchable bifunctional molecular recognition in water using a pH-responsive Endo-functionalized cavity
por: Wang, Xiaoping, et al.
Publicado: (2022)

Characterization and structure-activity relationships of indenoisoquinoline-derived topoisomerase I inhibitors in unsilencing the dormant Ube3a gene associated with Angelman syndrome
por: Lee, Hyeong-Min, et al.
Publicado: (2018)

Bifunctional Opioid/Melanocortin Peptidomimetics for Use in Neuropathic Pain: Variation in the Type and Length of the Linker Connecting the Two Pharmacophores
por: Witkowska, Ewa, et al.
Publicado: (2022)

Combination Treatment of Cervical Cancer Using Folate-Decorated, pH-Sensitive, Carboplatin and Paclitaxel Co-Loaded Lipid-Polymer Hybrid Nanoparticles
por: Wang, Junjian
Publicado: (2020)

Paradoxical Impact of Two Folate Receptors, FRα and RFC, in Ovarian Cancer: Effect on Cell Proliferation, Invasion and Clinical Outcome
por: Siu, Michelle K. Y., et al.
Publicado: (2012)

Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC
por: Rosario, Fredrick J., et al.
Publicado: (2016)

Folate Receptor β (FRβ) Expression in Tissue-Resident and Tumor-Associated Macrophages Associates with and Depends on the Expression of PU.1
por: Samaniego, Rafael, et al.
Publicado: (2020)

Predict the Progression of Cervical Intraepithelial Neoplasia by a Novel Marker Folate Combine with FRα, p16 and Ki-67
por: Liu, Tingting, et al.
Publicado: (2022)

Coordination engineering of iridium nanocluster bifunctional electrocatalyst for highly efficient and pH-universal overall water splitting
por: Wang, Qilun, et al.
Publicado: (2020)

Fr hjahrstagung
por: Schötzau, H J
Publicado: (1994)

β-Cyclodextrin conjugated bifunctional isocyanate linker polymer for enhanced removal of 2,4-dinitrophenol from environmental waters
por: Anne, J. M., et al.
Publicado: (2018)

A paclitaxel prodrug with bifunctional folate and albumin binding moieties for both passive and active targeted cancer therapy
por: Shan, Lingling, et al.
Publicado: (2018)

Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis
por: Zhao, Jinlong, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_ntkjfmu60pm5sdd80oo89qbap5