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Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

[Image: see text] Members of the bromodomain and extra terminal (BET) family of proteins are essential for the recognition of acetylated lysine (KAc) residues in histones and have emerged as promising drug targets in cancer, inflammation, and contraception research. In co-crystallization screening c...

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Detalles Bibliográficos
Autores principales:	Ember, Stuart W. J., Zhu, Jin-Yi, Olesen, Sanne H., Martin, Mathew P., Becker, Andreas, Berndt, Norbert, Georg, Gunda I., Schönbrunn, Ernst
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032195/ https://www.ncbi.nlm.nih.gov/pubmed/24568369 http://dx.doi.org/10.1021/cb500072z

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