Metformin Induces Apoptosis and Cell Cycle Arrest Mediated by Oxidative Stress, AMPK and FOXO3a in MCF-7 Breast Cancer Cells

Recent studies have demonstrated that the anti-diabetic drug, metformin, can exhibit direct antitumoral effects, or can indirectly decrease tumor proliferation by improving insulin sensitivity. Despite these recent advances, the underlying molecular mechanisms involved in decreasing tumor formation...

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Detalles Bibliográficos
Autores principales: Queiroz, Eveline A. I. F., Puukila, Stephanie, Eichler, Rosangela, Sampaio, Sandra C., Forsyth, Heidi L., Lees, Simon J., Barbosa, Aneli M., Dekker, Robert F. H., Fortes, Zuleica B., Khaper, Neelam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032293/
https://www.ncbi.nlm.nih.gov/pubmed/24858012
http://dx.doi.org/10.1371/journal.pone.0098207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032293/
https://www.ncbi.nlm.nih.gov/pubmed/24858012
http://dx.doi.org/10.1371/journal.pone.0098207

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