Integrated Proteomics Identified Up-Regulated Focal Adhesion-Mediated Proteins in Human Squamous Cell Carcinoma in an Orthotopic Murine Model

Understanding the molecular mechanisms of oral carcinogenesis will yield important advances in diagnostics, prognostics, effective treatment, and outcome of oral cancer. Hence, in this study we have investigated the proteomic and peptidomic profiles by combining an orthotopic murine model of oral sq...

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Detalles Bibliográficos
Autores principales: Granato, Daniela C., Zanetti, Mariana R., Kawahara, Rebeca, Yokoo, Sami, Domingues, Romênia R., Aragão, Annelize Z., Agostini, Michelle, Carazzolle, Marcelo F., Vidal, Ramon O., Flores, Isadora L., Korvala, Johanna, Cervigne, Nilva K., Silva, Alan R. S., Coletta, Ricardo D., Graner, Edgard, Sherman, Nicholas E., Leme, Adriana F. Paes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032327/
https://www.ncbi.nlm.nih.gov/pubmed/24858105
http://dx.doi.org/10.1371/journal.pone.0098208
Descripción
Sumario:Understanding the molecular mechanisms of oral carcinogenesis will yield important advances in diagnostics, prognostics, effective treatment, and outcome of oral cancer. Hence, in this study we have investigated the proteomic and peptidomic profiles by combining an orthotopic murine model of oral squamous cell carcinoma (OSCC), mass spectrometry-based proteomics and biological network analysis. Our results indicated the up-regulation of proteins involved in actin cytoskeleton organization and cell-cell junction assembly events and their expression was validated in human OSCC tissues. In addition, the functional relevance of talin-1 in OSCC adhesion, migration and invasion was demonstrated. Taken together, this study identified specific processes deregulated in oral cancer and provided novel refined OSCC-targeting molecules.

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