Cargando…
FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells
In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032333/ https://www.ncbi.nlm.nih.gov/pubmed/24857950 http://dx.doi.org/10.1371/journal.pone.0098041 |
_version_ | 1782317633222213632 |
---|---|
author | Zhu, Min Li, Mingyang Zhang, Fan Feng, Fan Chen, Weihao Yang, Yutao Cui, Jiajun Zhang, Dong Linghu, Enqiang |
author_facet | Zhu, Min Li, Mingyang Zhang, Fan Feng, Fan Chen, Weihao Yang, Yutao Cui, Jiajun Zhang, Dong Linghu, Enqiang |
author_sort | Zhu, Min |
collection | PubMed |
description | In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target genes and increase ETS-1 accumulation in the nuclear. Our work also indicated that the FBI-1 enhances ETS-1 transcription factor activity via down-regulating p53-mediated inhibition on ETS-1. Further, FBI-1 plays a role in regulation of colorectal carcinoma cells proliferation. These findings supported that FBI-1 might be a potential molecule target for treating colorectal carcinoma. |
format | Online Article Text |
id | pubmed-4032333 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40323332014-05-28 FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells Zhu, Min Li, Mingyang Zhang, Fan Feng, Fan Chen, Weihao Yang, Yutao Cui, Jiajun Zhang, Dong Linghu, Enqiang PLoS One Research Article In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target genes and increase ETS-1 accumulation in the nuclear. Our work also indicated that the FBI-1 enhances ETS-1 transcription factor activity via down-regulating p53-mediated inhibition on ETS-1. Further, FBI-1 plays a role in regulation of colorectal carcinoma cells proliferation. These findings supported that FBI-1 might be a potential molecule target for treating colorectal carcinoma. Public Library of Science 2014-05-23 /pmc/articles/PMC4032333/ /pubmed/24857950 http://dx.doi.org/10.1371/journal.pone.0098041 Text en © 2014 Zhu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Zhu, Min Li, Mingyang Zhang, Fan Feng, Fan Chen, Weihao Yang, Yutao Cui, Jiajun Zhang, Dong Linghu, Enqiang FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells |
title | FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells |
title_full | FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells |
title_fullStr | FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells |
title_full_unstemmed | FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells |
title_short | FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells |
title_sort | fbi-1 enhances ets-1 signaling activity and promotes proliferation of human colorectal carcinoma cells |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032333/ https://www.ncbi.nlm.nih.gov/pubmed/24857950 http://dx.doi.org/10.1371/journal.pone.0098041 |
work_keys_str_mv | AT zhumin fbi1enhancesets1signalingactivityandpromotesproliferationofhumancolorectalcarcinomacells AT limingyang fbi1enhancesets1signalingactivityandpromotesproliferationofhumancolorectalcarcinomacells AT zhangfan fbi1enhancesets1signalingactivityandpromotesproliferationofhumancolorectalcarcinomacells AT fengfan fbi1enhancesets1signalingactivityandpromotesproliferationofhumancolorectalcarcinomacells AT chenweihao fbi1enhancesets1signalingactivityandpromotesproliferationofhumancolorectalcarcinomacells AT yangyutao fbi1enhancesets1signalingactivityandpromotesproliferationofhumancolorectalcarcinomacells AT cuijiajun fbi1enhancesets1signalingactivityandpromotesproliferationofhumancolorectalcarcinomacells AT zhangdong fbi1enhancesets1signalingactivityandpromotesproliferationofhumancolorectalcarcinomacells AT linghuenqiang fbi1enhancesets1signalingactivityandpromotesproliferationofhumancolorectalcarcinomacells |