FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells

In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target...

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Detalles Bibliográficos
Autores principales: Zhu, Min, Li, Mingyang, Zhang, Fan, Feng, Fan, Chen, Weihao, Yang, Yutao, Cui, Jiajun, Zhang, Dong, Linghu, Enqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032333/
https://www.ncbi.nlm.nih.gov/pubmed/24857950
http://dx.doi.org/10.1371/journal.pone.0098041
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author Zhu, Min
Li, Mingyang
Zhang, Fan
Feng, Fan
Chen, Weihao
Yang, Yutao
Cui, Jiajun
Zhang, Dong
Linghu, Enqiang
author_facet Zhu, Min
Li, Mingyang
Zhang, Fan
Feng, Fan
Chen, Weihao
Yang, Yutao
Cui, Jiajun
Zhang, Dong
Linghu, Enqiang
author_sort Zhu, Min
collection PubMed
description In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target genes and increase ETS-1 accumulation in the nuclear. Our work also indicated that the FBI-1 enhances ETS-1 transcription factor activity via down-regulating p53-mediated inhibition on ETS-1. Further, FBI-1 plays a role in regulation of colorectal carcinoma cells proliferation. These findings supported that FBI-1 might be a potential molecule target for treating colorectal carcinoma.
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spelling pubmed-40323332014-05-28 FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells Zhu, Min Li, Mingyang Zhang, Fan Feng, Fan Chen, Weihao Yang, Yutao Cui, Jiajun Zhang, Dong Linghu, Enqiang PLoS One Research Article In this study, we investigated a potential regulatory role of FBI-1 in transcription factor activity of ETS-1. The protein interaction was identified between ETS-1 and FBI-1 in lovo cells. The accumulating data showed that FBI-1 promoted the recruitment of ETS-1 to endogenous promoter of its target genes and increase ETS-1 accumulation in the nuclear. Our work also indicated that the FBI-1 enhances ETS-1 transcription factor activity via down-regulating p53-mediated inhibition on ETS-1. Further, FBI-1 plays a role in regulation of colorectal carcinoma cells proliferation. These findings supported that FBI-1 might be a potential molecule target for treating colorectal carcinoma. Public Library of Science 2014-05-23 /pmc/articles/PMC4032333/ /pubmed/24857950 http://dx.doi.org/10.1371/journal.pone.0098041 Text en © 2014 Zhu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zhu, Min
Li, Mingyang
Zhang, Fan
Feng, Fan
Chen, Weihao
Yang, Yutao
Cui, Jiajun
Zhang, Dong
Linghu, Enqiang
FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells
title FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells
title_full FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells
title_fullStr FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells
title_full_unstemmed FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells
title_short FBI-1 Enhances ETS-1 Signaling Activity and Promotes Proliferation of Human Colorectal Carcinoma Cells
title_sort fbi-1 enhances ets-1 signaling activity and promotes proliferation of human colorectal carcinoma cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032333/
https://www.ncbi.nlm.nih.gov/pubmed/24857950
http://dx.doi.org/10.1371/journal.pone.0098041
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