Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN-deficient human fibroblasts

Werner syndrome (WS), caused by mutations at the WRN helicase gene, is a progeroid syndrome characterized by multiple features consistent with accelerated aging. Aberrant double-strand DNA damage repair leads to genomic instability and reduced replicative lifespan of somatic cells. We observed incre...

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Detalles Bibliográficos
Autores principales: Saha, Bidisha, Cypro, Alexander, Martin, George M, Oshima, Junko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Short Takes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032596/
https://www.ncbi.nlm.nih.gov/pubmed/24308646
http://dx.doi.org/10.1111/acel.12190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032596/
https://www.ncbi.nlm.nih.gov/pubmed/24308646
http://dx.doi.org/10.1111/acel.12190

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