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Formation of Microvascular Networks: Role of Stromal Interactions Directing Angiogenic Growth

In the adult, angiogenesis leads to an expanded microvascular network as new vessel segments are added to an existing microcirculation. Necessarily, growing neovessels must navigate through tissue stroma as they locate and grow toward other vessel elements. We have a growing body of evidence demonst...

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Detalles Bibliográficos
Autores principales: Hoying, James B, Utzinger, Urs, Weiss, Jeffrey A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032604/
https://www.ncbi.nlm.nih.gov/pubmed/24447042
http://dx.doi.org/10.1111/micc.12115
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author Hoying, James B
Utzinger, Urs
Weiss, Jeffrey A
author_facet Hoying, James B
Utzinger, Urs
Weiss, Jeffrey A
author_sort Hoying, James B
collection PubMed
description In the adult, angiogenesis leads to an expanded microvascular network as new vessel segments are added to an existing microcirculation. Necessarily, growing neovessels must navigate through tissue stroma as they locate and grow toward other vessel elements. We have a growing body of evidence demonstrating that angiogenic neovessels reciprocally interact with the interstitial matrix of the stroma resulting in directed neovascular growth during angiogenesis. Given the compliance and the viscoelastic properties of collagen, neovessel guidance by the stroma is likely due to compressive strain transverse to the direction of primary tensile forces present during active tissue deformation. Similar stromal strains control the final network topology of the new microcirculation, including the distribution of arterioles, capillaries, and venules. In this case, stromal-derived stimuli must be present during the post-angiogenesis remodeling and maturation phases of neovascularization to have this effect. Interestingly, the preexisting organization of vessels prior to the start of angiogenesis has no lasting influence on the final, new network architecture. Combined, the evidence describes interplay between angiogenic neovessels and stroma that is important in directed neovessel growth and invasion. This dynamic is also likely a mechanism by which global tissue forces influence vascular form and function.
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spelling pubmed-40326042014-12-11 Formation of Microvascular Networks: Role of Stromal Interactions Directing Angiogenic Growth Hoying, James B Utzinger, Urs Weiss, Jeffrey A Microcirculation Invited Reviews In the adult, angiogenesis leads to an expanded microvascular network as new vessel segments are added to an existing microcirculation. Necessarily, growing neovessels must navigate through tissue stroma as they locate and grow toward other vessel elements. We have a growing body of evidence demonstrating that angiogenic neovessels reciprocally interact with the interstitial matrix of the stroma resulting in directed neovascular growth during angiogenesis. Given the compliance and the viscoelastic properties of collagen, neovessel guidance by the stroma is likely due to compressive strain transverse to the direction of primary tensile forces present during active tissue deformation. Similar stromal strains control the final network topology of the new microcirculation, including the distribution of arterioles, capillaries, and venules. In this case, stromal-derived stimuli must be present during the post-angiogenesis remodeling and maturation phases of neovascularization to have this effect. Interestingly, the preexisting organization of vessels prior to the start of angiogenesis has no lasting influence on the final, new network architecture. Combined, the evidence describes interplay between angiogenic neovessels and stroma that is important in directed neovessel growth and invasion. This dynamic is also likely a mechanism by which global tissue forces influence vascular form and function. Blackwell Publishing Ltd 2014-05 2014-05-22 /pmc/articles/PMC4032604/ /pubmed/24447042 http://dx.doi.org/10.1111/micc.12115 Text en Copyright © 2014 John Wiley & Sons Ltd http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Invited Reviews
Hoying, James B
Utzinger, Urs
Weiss, Jeffrey A
Formation of Microvascular Networks: Role of Stromal Interactions Directing Angiogenic Growth
title Formation of Microvascular Networks: Role of Stromal Interactions Directing Angiogenic Growth
title_full Formation of Microvascular Networks: Role of Stromal Interactions Directing Angiogenic Growth
title_fullStr Formation of Microvascular Networks: Role of Stromal Interactions Directing Angiogenic Growth
title_full_unstemmed Formation of Microvascular Networks: Role of Stromal Interactions Directing Angiogenic Growth
title_short Formation of Microvascular Networks: Role of Stromal Interactions Directing Angiogenic Growth
title_sort formation of microvascular networks: role of stromal interactions directing angiogenic growth
topic Invited Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032604/
https://www.ncbi.nlm.nih.gov/pubmed/24447042
http://dx.doi.org/10.1111/micc.12115
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