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Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells
Early and late endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT). This review summarizes main endocrine disorders reported in literature and observed in our center as consequence of aut...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032698/ https://www.ncbi.nlm.nih.gov/pubmed/24883377 http://dx.doi.org/10.1155/2014/282147 |
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author | Orio, Francesco Muscogiuri, Giovanna Palomba, Stefano Serio, Bianca Sessa, Mariarosaria Giudice, Valentina Ferrara, Idalucia Tauchmanovà, Libuse Colao, Annamaria Selleri, Carmine |
author_facet | Orio, Francesco Muscogiuri, Giovanna Palomba, Stefano Serio, Bianca Sessa, Mariarosaria Giudice, Valentina Ferrara, Idalucia Tauchmanovà, Libuse Colao, Annamaria Selleri, Carmine |
author_sort | Orio, Francesco |
collection | PubMed |
description | Early and late endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT). This review summarizes main endocrine disorders reported in literature and observed in our center as consequence of auto- and allo-HSCT and outlines current options for their management. Gonadal impairment has been found early in approximately two-thirds of auto- and allo-HSCT patients: 90–99% of women and 60–90% of men. Dysfunctions of the hypothalamus-pituitary-growth hormone/insulin growth factor-I axis, hypothalamus-pituitary-thyroid axis, and hypothalamus-pituitary-adrenal axis were documented as later complicances, occurring in about 10, 30, and 40–50% of transplanted patients, respectively. Moreover, overt or subclinical thyroid complications (including persistent low-T3 syndrome, chronic thyroiditis, subclinical hypo- or hyperthyroidism, and thyroid carcinoma), gonadal failure, and adrenal insufficiency may persist many years after HSCT. Our analysis further provides evidence that main recognized risk factors for endocrine complications after HSCT are the underlying disease, previous pretransplant therapies, the age at HSCT, gender, total body irradiation, posttransplant derangement of immune system, and in the allogeneic setting, the presence of graft-versus-host disease requiring prolonged steroid treatment. Early identification of endocrine complications can greatly improve the quality of life of long-term survivors after HSCT. |
format | Online Article Text |
id | pubmed-4032698 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40326982014-06-01 Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells Orio, Francesco Muscogiuri, Giovanna Palomba, Stefano Serio, Bianca Sessa, Mariarosaria Giudice, Valentina Ferrara, Idalucia Tauchmanovà, Libuse Colao, Annamaria Selleri, Carmine ScientificWorldJournal Review Article Early and late endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT). This review summarizes main endocrine disorders reported in literature and observed in our center as consequence of auto- and allo-HSCT and outlines current options for their management. Gonadal impairment has been found early in approximately two-thirds of auto- and allo-HSCT patients: 90–99% of women and 60–90% of men. Dysfunctions of the hypothalamus-pituitary-growth hormone/insulin growth factor-I axis, hypothalamus-pituitary-thyroid axis, and hypothalamus-pituitary-adrenal axis were documented as later complicances, occurring in about 10, 30, and 40–50% of transplanted patients, respectively. Moreover, overt or subclinical thyroid complications (including persistent low-T3 syndrome, chronic thyroiditis, subclinical hypo- or hyperthyroidism, and thyroid carcinoma), gonadal failure, and adrenal insufficiency may persist many years after HSCT. Our analysis further provides evidence that main recognized risk factors for endocrine complications after HSCT are the underlying disease, previous pretransplant therapies, the age at HSCT, gender, total body irradiation, posttransplant derangement of immune system, and in the allogeneic setting, the presence of graft-versus-host disease requiring prolonged steroid treatment. Early identification of endocrine complications can greatly improve the quality of life of long-term survivors after HSCT. Hindawi Publishing Corporation 2014 2014-04-30 /pmc/articles/PMC4032698/ /pubmed/24883377 http://dx.doi.org/10.1155/2014/282147 Text en Copyright © 2014 Francesco Orio et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Orio, Francesco Muscogiuri, Giovanna Palomba, Stefano Serio, Bianca Sessa, Mariarosaria Giudice, Valentina Ferrara, Idalucia Tauchmanovà, Libuse Colao, Annamaria Selleri, Carmine Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells |
title | Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells |
title_full | Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells |
title_fullStr | Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells |
title_full_unstemmed | Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells |
title_short | Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells |
title_sort | endocrinopathies after allogeneic and autologous transplantation of hematopoietic stem cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032698/ https://www.ncbi.nlm.nih.gov/pubmed/24883377 http://dx.doi.org/10.1155/2014/282147 |
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