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Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells

Early and late endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT). This review summarizes main endocrine disorders reported in literature and observed in our center as consequence of aut...

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Autores principales: Orio, Francesco, Muscogiuri, Giovanna, Palomba, Stefano, Serio, Bianca, Sessa, Mariarosaria, Giudice, Valentina, Ferrara, Idalucia, Tauchmanovà, Libuse, Colao, Annamaria, Selleri, Carmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032698/
https://www.ncbi.nlm.nih.gov/pubmed/24883377
http://dx.doi.org/10.1155/2014/282147
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author Orio, Francesco
Muscogiuri, Giovanna
Palomba, Stefano
Serio, Bianca
Sessa, Mariarosaria
Giudice, Valentina
Ferrara, Idalucia
Tauchmanovà, Libuse
Colao, Annamaria
Selleri, Carmine
author_facet Orio, Francesco
Muscogiuri, Giovanna
Palomba, Stefano
Serio, Bianca
Sessa, Mariarosaria
Giudice, Valentina
Ferrara, Idalucia
Tauchmanovà, Libuse
Colao, Annamaria
Selleri, Carmine
author_sort Orio, Francesco
collection PubMed
description Early and late endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT). This review summarizes main endocrine disorders reported in literature and observed in our center as consequence of auto- and allo-HSCT and outlines current options for their management. Gonadal impairment has been found early in approximately two-thirds of auto- and allo-HSCT patients: 90–99% of women and 60–90% of men. Dysfunctions of the hypothalamus-pituitary-growth hormone/insulin growth factor-I axis, hypothalamus-pituitary-thyroid axis, and hypothalamus-pituitary-adrenal axis were documented as later complicances, occurring in about 10, 30, and 40–50% of transplanted patients, respectively. Moreover, overt or subclinical thyroid complications (including persistent low-T3 syndrome, chronic thyroiditis, subclinical hypo- or hyperthyroidism, and thyroid carcinoma), gonadal failure, and adrenal insufficiency may persist many years after HSCT. Our analysis further provides evidence that main recognized risk factors for endocrine complications after HSCT are the underlying disease, previous pretransplant therapies, the age at HSCT, gender, total body irradiation, posttransplant derangement of immune system, and in the allogeneic setting, the presence of graft-versus-host disease requiring prolonged steroid treatment. Early identification of endocrine complications can greatly improve the quality of life of long-term survivors after HSCT.
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spelling pubmed-40326982014-06-01 Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells Orio, Francesco Muscogiuri, Giovanna Palomba, Stefano Serio, Bianca Sessa, Mariarosaria Giudice, Valentina Ferrara, Idalucia Tauchmanovà, Libuse Colao, Annamaria Selleri, Carmine ScientificWorldJournal Review Article Early and late endocrine disorders are among the most common complications in survivors after hematopoietic allogeneic- (allo-) and autologous- (auto-) stem cell transplant (HSCT). This review summarizes main endocrine disorders reported in literature and observed in our center as consequence of auto- and allo-HSCT and outlines current options for their management. Gonadal impairment has been found early in approximately two-thirds of auto- and allo-HSCT patients: 90–99% of women and 60–90% of men. Dysfunctions of the hypothalamus-pituitary-growth hormone/insulin growth factor-I axis, hypothalamus-pituitary-thyroid axis, and hypothalamus-pituitary-adrenal axis were documented as later complicances, occurring in about 10, 30, and 40–50% of transplanted patients, respectively. Moreover, overt or subclinical thyroid complications (including persistent low-T3 syndrome, chronic thyroiditis, subclinical hypo- or hyperthyroidism, and thyroid carcinoma), gonadal failure, and adrenal insufficiency may persist many years after HSCT. Our analysis further provides evidence that main recognized risk factors for endocrine complications after HSCT are the underlying disease, previous pretransplant therapies, the age at HSCT, gender, total body irradiation, posttransplant derangement of immune system, and in the allogeneic setting, the presence of graft-versus-host disease requiring prolonged steroid treatment. Early identification of endocrine complications can greatly improve the quality of life of long-term survivors after HSCT. Hindawi Publishing Corporation 2014 2014-04-30 /pmc/articles/PMC4032698/ /pubmed/24883377 http://dx.doi.org/10.1155/2014/282147 Text en Copyright © 2014 Francesco Orio et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Orio, Francesco
Muscogiuri, Giovanna
Palomba, Stefano
Serio, Bianca
Sessa, Mariarosaria
Giudice, Valentina
Ferrara, Idalucia
Tauchmanovà, Libuse
Colao, Annamaria
Selleri, Carmine
Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells
title Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells
title_full Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells
title_fullStr Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells
title_full_unstemmed Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells
title_short Endocrinopathies after Allogeneic and Autologous Transplantation of Hematopoietic Stem Cells
title_sort endocrinopathies after allogeneic and autologous transplantation of hematopoietic stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032698/
https://www.ncbi.nlm.nih.gov/pubmed/24883377
http://dx.doi.org/10.1155/2014/282147
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