MicroRNA Machinery Genes as Novel Biomarkers for Cancer

MicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemica...

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Autores principales: Huang, Jing-Tao, Wang, Jin, Srivastava, Vibhuti, Sen, Subrata, Liu, Song-Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032885/
https://www.ncbi.nlm.nih.gov/pubmed/24904827
http://dx.doi.org/10.3389/fonc.2014.00113
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author Huang, Jing-Tao
Wang, Jin
Srivastava, Vibhuti
Sen, Subrata
Liu, Song-Mei
author_facet Huang, Jing-Tao
Wang, Jin
Srivastava, Vibhuti
Sen, Subrata
Liu, Song-Mei
author_sort Huang, Jing-Tao
collection PubMed
description MicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemical capabilities in different cancers. Our preliminary analysis of data from The Cancer Genome Atlas consortium on multiple types of cancer revealed significant alterations in these miRNA machinery genes. Here, we review their biological structures and functions with an eye toward understanding how they could serve as cancer biomarkers.
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spelling pubmed-40328852014-06-05 MicroRNA Machinery Genes as Novel Biomarkers for Cancer Huang, Jing-Tao Wang, Jin Srivastava, Vibhuti Sen, Subrata Liu, Song-Mei Front Oncol Oncology MicroRNAs (miRNAs) directly and indirectly affect tumorigenesis. To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs. These genes have specific expression patterns, protein-binding partners, and biochemical capabilities in different cancers. Our preliminary analysis of data from The Cancer Genome Atlas consortium on multiple types of cancer revealed significant alterations in these miRNA machinery genes. Here, we review their biological structures and functions with an eye toward understanding how they could serve as cancer biomarkers. Frontiers Media S.A. 2014-05-19 /pmc/articles/PMC4032885/ /pubmed/24904827 http://dx.doi.org/10.3389/fonc.2014.00113 Text en Copyright © 2014 Huang, Wang, Srivastava, Sen and Liu. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Huang, Jing-Tao
Wang, Jin
Srivastava, Vibhuti
Sen, Subrata
Liu, Song-Mei
MicroRNA Machinery Genes as Novel Biomarkers for Cancer
title MicroRNA Machinery Genes as Novel Biomarkers for Cancer
title_full MicroRNA Machinery Genes as Novel Biomarkers for Cancer
title_fullStr MicroRNA Machinery Genes as Novel Biomarkers for Cancer
title_full_unstemmed MicroRNA Machinery Genes as Novel Biomarkers for Cancer
title_short MicroRNA Machinery Genes as Novel Biomarkers for Cancer
title_sort microrna machinery genes as novel biomarkers for cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032885/
https://www.ncbi.nlm.nih.gov/pubmed/24904827
http://dx.doi.org/10.3389/fonc.2014.00113
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