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The Life and Fate of Mesenchymal Stem Cells

Mesenchymal stem cells (MSC) are present throughout the body and are thought to play a role in tissue regeneration and control of inflammation. MSC can be easily expanded in vitro and their potential as a therapeutic option for degenerative and inflammatory disease is therefore intensively investiga...

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Autores principales: Eggenhofer, Elke, Luk, Franka, Dahlke, Marc H., Hoogduijn, Martin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032901/
https://www.ncbi.nlm.nih.gov/pubmed/24904568
http://dx.doi.org/10.3389/fimmu.2014.00148
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author Eggenhofer, Elke
Luk, Franka
Dahlke, Marc H.
Hoogduijn, Martin J.
author_facet Eggenhofer, Elke
Luk, Franka
Dahlke, Marc H.
Hoogduijn, Martin J.
author_sort Eggenhofer, Elke
collection PubMed
description Mesenchymal stem cells (MSC) are present throughout the body and are thought to play a role in tissue regeneration and control of inflammation. MSC can be easily expanded in vitro and their potential as a therapeutic option for degenerative and inflammatory disease is therefore intensively investigated. Whilst it was initially thought that MSC would replace dysfunctional cells and migrate to sites of injury to interact with inflammatory cells, experimental evidence indicates that the majority of administered MSC get trapped in capillary networks and have a short life span. In this review, we discuss current knowledge on the migratory properties of endogenous and exogenous MSC and confer on how culture-induced modifications of MSC may affect these properties. Finally, we will discuss how, despite their limited survival, administered MSC can bring about their therapeutic effects.
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spelling pubmed-40329012014-06-05 The Life and Fate of Mesenchymal Stem Cells Eggenhofer, Elke Luk, Franka Dahlke, Marc H. Hoogduijn, Martin J. Front Immunol Immunology Mesenchymal stem cells (MSC) are present throughout the body and are thought to play a role in tissue regeneration and control of inflammation. MSC can be easily expanded in vitro and their potential as a therapeutic option for degenerative and inflammatory disease is therefore intensively investigated. Whilst it was initially thought that MSC would replace dysfunctional cells and migrate to sites of injury to interact with inflammatory cells, experimental evidence indicates that the majority of administered MSC get trapped in capillary networks and have a short life span. In this review, we discuss current knowledge on the migratory properties of endogenous and exogenous MSC and confer on how culture-induced modifications of MSC may affect these properties. Finally, we will discuss how, despite their limited survival, administered MSC can bring about their therapeutic effects. Frontiers Media S.A. 2014-05-19 /pmc/articles/PMC4032901/ /pubmed/24904568 http://dx.doi.org/10.3389/fimmu.2014.00148 Text en Copyright © 2014 Eggenhofer, Luk, Dahlke and Hoogduijn. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Eggenhofer, Elke
Luk, Franka
Dahlke, Marc H.
Hoogduijn, Martin J.
The Life and Fate of Mesenchymal Stem Cells
title The Life and Fate of Mesenchymal Stem Cells
title_full The Life and Fate of Mesenchymal Stem Cells
title_fullStr The Life and Fate of Mesenchymal Stem Cells
title_full_unstemmed The Life and Fate of Mesenchymal Stem Cells
title_short The Life and Fate of Mesenchymal Stem Cells
title_sort life and fate of mesenchymal stem cells
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032901/
https://www.ncbi.nlm.nih.gov/pubmed/24904568
http://dx.doi.org/10.3389/fimmu.2014.00148
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