Cargando…

Insights into the structure and architecture of the CCR4–NOT complex

The CCR4–NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription initiation and elongation, ubiquitination, and p...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Kun, Bai, Yuwei, Zhang, Aili, Zhang, Qionglin, Bartlam, Mark G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032980/
https://www.ncbi.nlm.nih.gov/pubmed/24904637
http://dx.doi.org/10.3389/fgene.2014.00137
_version_ 1782317734467469312
author Xu, Kun
Bai, Yuwei
Zhang, Aili
Zhang, Qionglin
Bartlam, Mark G.
author_facet Xu, Kun
Bai, Yuwei
Zhang, Aili
Zhang, Qionglin
Bartlam, Mark G.
author_sort Xu, Kun
collection PubMed
description The CCR4–NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription initiation and elongation, ubiquitination, and protein modification. The core CCR4–NOT complex is evolutionarily conserved and consists of at least three NOT proteins and two catalytic subunits. The L-shaped complex is characterized by two functional modules bound to the CNOT1/Not1 scaffold protein: the deadenylase or nuclease module containing two enzymes required for deadenylation, and the NOT module. In this review, we will summarize the currently available information regarding the three-dimensional structure and assembly of the CCR4–NOT complex, in order to provide insight into its roles in mRNA degradation and other biological processes.
format Online
Article
Text
id pubmed-4032980
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-40329802014-06-05 Insights into the structure and architecture of the CCR4–NOT complex Xu, Kun Bai, Yuwei Zhang, Aili Zhang, Qionglin Bartlam, Mark G. Front Genet Genetics The CCR4–NOT complex is a highly conserved, multifunctional machinery with a general role in controlling mRNA metabolism. It has been implicated in a number of different aspects of mRNA and protein expression, including mRNA degradation, transcription initiation and elongation, ubiquitination, and protein modification. The core CCR4–NOT complex is evolutionarily conserved and consists of at least three NOT proteins and two catalytic subunits. The L-shaped complex is characterized by two functional modules bound to the CNOT1/Not1 scaffold protein: the deadenylase or nuclease module containing two enzymes required for deadenylation, and the NOT module. In this review, we will summarize the currently available information regarding the three-dimensional structure and assembly of the CCR4–NOT complex, in order to provide insight into its roles in mRNA degradation and other biological processes. Frontiers Media S.A. 2014-05-16 /pmc/articles/PMC4032980/ /pubmed/24904637 http://dx.doi.org/10.3389/fgene.2014.00137 Text en Copyright © 2014 Xu, Bai, Zhang, Zhang and Bartlam. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Xu, Kun
Bai, Yuwei
Zhang, Aili
Zhang, Qionglin
Bartlam, Mark G.
Insights into the structure and architecture of the CCR4–NOT complex
title Insights into the structure and architecture of the CCR4–NOT complex
title_full Insights into the structure and architecture of the CCR4–NOT complex
title_fullStr Insights into the structure and architecture of the CCR4–NOT complex
title_full_unstemmed Insights into the structure and architecture of the CCR4–NOT complex
title_short Insights into the structure and architecture of the CCR4–NOT complex
title_sort insights into the structure and architecture of the ccr4–not complex
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032980/
https://www.ncbi.nlm.nih.gov/pubmed/24904637
http://dx.doi.org/10.3389/fgene.2014.00137
work_keys_str_mv AT xukun insightsintothestructureandarchitectureoftheccr4notcomplex
AT baiyuwei insightsintothestructureandarchitectureoftheccr4notcomplex
AT zhangaili insightsintothestructureandarchitectureoftheccr4notcomplex
AT zhangqionglin insightsintothestructureandarchitectureoftheccr4notcomplex
AT bartlammarkg insightsintothestructureandarchitectureoftheccr4notcomplex