Lipid domains in HIV-1 assembly

In CD(+)(4) T cells, HIV-1 buds from the host cell plasma membrane. The viral Gag polyprotein is mainly responsible for this process. However, the intimate interaction of Gag and lipids at the plasma membrane as well as its consequences, in terms of lipids lateral organization and virus assembly, is...

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Detalles Bibliográficos
Autores principales: Yandrapalli, Naresh, Muriaux, Delphine, Favard, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033000/
https://www.ncbi.nlm.nih.gov/pubmed/24904536
http://dx.doi.org/10.3389/fmicb.2014.00220
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author Yandrapalli, Naresh
Muriaux, Delphine
Favard, Cyril
author_facet Yandrapalli, Naresh
Muriaux, Delphine
Favard, Cyril
author_sort Yandrapalli, Naresh
collection PubMed
description In CD(+)(4) T cells, HIV-1 buds from the host cell plasma membrane. The viral Gag polyprotein is mainly responsible for this process. However, the intimate interaction of Gag and lipids at the plasma membrane as well as its consequences, in terms of lipids lateral organization and virus assembly, is still under debate. In this review we propose to revisit the role of plasma membrane lipids in HIV-1 Gag targeting and assembly, at the light of lipid membranes biophysics and literature dealing with Gag-lipid interactions.
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spelling pubmed-40330002014-06-05 Lipid domains in HIV-1 assembly Yandrapalli, Naresh Muriaux, Delphine Favard, Cyril Front Microbiol Microbiology In CD(+)(4) T cells, HIV-1 buds from the host cell plasma membrane. The viral Gag polyprotein is mainly responsible for this process. However, the intimate interaction of Gag and lipids at the plasma membrane as well as its consequences, in terms of lipids lateral organization and virus assembly, is still under debate. In this review we propose to revisit the role of plasma membrane lipids in HIV-1 Gag targeting and assembly, at the light of lipid membranes biophysics and literature dealing with Gag-lipid interactions. Frontiers Media S.A. 2014-05-19 /pmc/articles/PMC4033000/ /pubmed/24904536 http://dx.doi.org/10.3389/fmicb.2014.00220 Text en Copyright © 2014 Yandrapalli, Muriaux and Favard. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Yandrapalli, Naresh
Muriaux, Delphine
Favard, Cyril
Lipid domains in HIV-1 assembly
title Lipid domains in HIV-1 assembly
title_full Lipid domains in HIV-1 assembly
title_fullStr Lipid domains in HIV-1 assembly
title_full_unstemmed Lipid domains in HIV-1 assembly
title_short Lipid domains in HIV-1 assembly
title_sort lipid domains in hiv-1 assembly
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033000/
https://www.ncbi.nlm.nih.gov/pubmed/24904536
http://dx.doi.org/10.3389/fmicb.2014.00220
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