Phagosomal TLR signaling upon Borrelia burgdorferi infection

Internalization and degradation of live Bb within phagosomal compartments of monocytes, macrophages and dendritic cells (DCs), allows for the release of lipoproteins, nucleic acids and other microbial products, triggering a broad and robust inflammatory response. Toll-like receptors (TLRs) are key p...

Descripción completa

Detalles Bibliográficos
Autores principales: Cervantes, Jorge L., Hawley, Kelly L., Benjamin, Sarah J., Weinerman, Bennett, Luu, Stephanie M., Salazar, Juan C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033037/
https://www.ncbi.nlm.nih.gov/pubmed/24904837
http://dx.doi.org/10.3389/fcimb.2014.00055
_version_ 1782317747883999232
author Cervantes, Jorge L.
Hawley, Kelly L.
Benjamin, Sarah J.
Weinerman, Bennett
Luu, Stephanie M.
Salazar, Juan C.
author_facet Cervantes, Jorge L.
Hawley, Kelly L.
Benjamin, Sarah J.
Weinerman, Bennett
Luu, Stephanie M.
Salazar, Juan C.
author_sort Cervantes, Jorge L.
collection PubMed
description Internalization and degradation of live Bb within phagosomal compartments of monocytes, macrophages and dendritic cells (DCs), allows for the release of lipoproteins, nucleic acids and other microbial products, triggering a broad and robust inflammatory response. Toll-like receptors (TLRs) are key players in the recognition of spirochetal ligands from whole viable organisms (i.e., vita-PAMPs). Herein we will review the role of endosomal TLRs in the response to the Lyme disease spirochete.
format Online
Article
Text
id pubmed-4033037
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-40330372014-06-05 Phagosomal TLR signaling upon Borrelia burgdorferi infection Cervantes, Jorge L. Hawley, Kelly L. Benjamin, Sarah J. Weinerman, Bennett Luu, Stephanie M. Salazar, Juan C. Front Cell Infect Microbiol Microbiology Internalization and degradation of live Bb within phagosomal compartments of monocytes, macrophages and dendritic cells (DCs), allows for the release of lipoproteins, nucleic acids and other microbial products, triggering a broad and robust inflammatory response. Toll-like receptors (TLRs) are key players in the recognition of spirochetal ligands from whole viable organisms (i.e., vita-PAMPs). Herein we will review the role of endosomal TLRs in the response to the Lyme disease spirochete. Frontiers Media S.A. 2014-05-20 /pmc/articles/PMC4033037/ /pubmed/24904837 http://dx.doi.org/10.3389/fcimb.2014.00055 Text en Copyright © 2014 Cervantes, Hawley, Benjamin, Weinerman, Luu and Salazar. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Cervantes, Jorge L.
Hawley, Kelly L.
Benjamin, Sarah J.
Weinerman, Bennett
Luu, Stephanie M.
Salazar, Juan C.
Phagosomal TLR signaling upon Borrelia burgdorferi infection
title Phagosomal TLR signaling upon Borrelia burgdorferi infection
title_full Phagosomal TLR signaling upon Borrelia burgdorferi infection
title_fullStr Phagosomal TLR signaling upon Borrelia burgdorferi infection
title_full_unstemmed Phagosomal TLR signaling upon Borrelia burgdorferi infection
title_short Phagosomal TLR signaling upon Borrelia burgdorferi infection
title_sort phagosomal tlr signaling upon borrelia burgdorferi infection
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033037/
https://www.ncbi.nlm.nih.gov/pubmed/24904837
http://dx.doi.org/10.3389/fcimb.2014.00055
work_keys_str_mv AT cervantesjorgel phagosomaltlrsignalinguponborreliaburgdorferiinfection
AT hawleykellyl phagosomaltlrsignalinguponborreliaburgdorferiinfection
AT benjaminsarahj phagosomaltlrsignalinguponborreliaburgdorferiinfection
AT weinermanbennett phagosomaltlrsignalinguponborreliaburgdorferiinfection
AT luustephaniem phagosomaltlrsignalinguponborreliaburgdorferiinfection
AT salazarjuanc phagosomaltlrsignalinguponborreliaburgdorferiinfection

Ejemplares similares