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Allen Brain Atlas-Driven Visualizations: a web-based gene expression energy visualization tool

The Allen Brain Atlas-Driven Visualizations (ABADV) is a publicly accessible web-based tool created to retrieve and visualize expression energy data from the Allen Brain Atlas (ABA) across multiple genes and brain structures. Though the ABA offers their own search engine and software for researchers...

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Detalles Bibliográficos
Autores principales: Zaldivar, Andrew, Krichmar, Jeffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033128/
https://www.ncbi.nlm.nih.gov/pubmed/24904397
http://dx.doi.org/10.3389/fninf.2014.00051
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author Zaldivar, Andrew
Krichmar, Jeffrey L.
author_facet Zaldivar, Andrew
Krichmar, Jeffrey L.
author_sort Zaldivar, Andrew
collection PubMed
description The Allen Brain Atlas-Driven Visualizations (ABADV) is a publicly accessible web-based tool created to retrieve and visualize expression energy data from the Allen Brain Atlas (ABA) across multiple genes and brain structures. Though the ABA offers their own search engine and software for researchers to view their growing collection of online public data sets, including extensive gene expression and neuroanatomical data from human and mouse brain, many of their tools limit the amount of genes and brain structures researchers can view at once. To complement their work, ABADV generates multiple pie charts, bar charts and heat maps of expression energy values for any given set of genes and brain structures. Such a suite of free and easy-to-understand visualizations allows for easy comparison of gene expression across multiple brain areas. In addition, each visualization links back to the ABA so researchers may view a summary of the experimental detail. ABADV is currently supported on modern web browsers and is compatible with expression energy data from the Allen Mouse Brain Atlas in situ hybridization data. By creating this web application, researchers can immediately obtain and survey numerous amounts of expression energy data from the ABA, which they can then use to supplement their work or perform meta-analysis. In the future, we hope to enable ABADV across multiple data resources.
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spelling pubmed-40331282014-06-05 Allen Brain Atlas-Driven Visualizations: a web-based gene expression energy visualization tool Zaldivar, Andrew Krichmar, Jeffrey L. Front Neuroinform Neuroscience The Allen Brain Atlas-Driven Visualizations (ABADV) is a publicly accessible web-based tool created to retrieve and visualize expression energy data from the Allen Brain Atlas (ABA) across multiple genes and brain structures. Though the ABA offers their own search engine and software for researchers to view their growing collection of online public data sets, including extensive gene expression and neuroanatomical data from human and mouse brain, many of their tools limit the amount of genes and brain structures researchers can view at once. To complement their work, ABADV generates multiple pie charts, bar charts and heat maps of expression energy values for any given set of genes and brain structures. Such a suite of free and easy-to-understand visualizations allows for easy comparison of gene expression across multiple brain areas. In addition, each visualization links back to the ABA so researchers may view a summary of the experimental detail. ABADV is currently supported on modern web browsers and is compatible with expression energy data from the Allen Mouse Brain Atlas in situ hybridization data. By creating this web application, researchers can immediately obtain and survey numerous amounts of expression energy data from the ABA, which they can then use to supplement their work or perform meta-analysis. In the future, we hope to enable ABADV across multiple data resources. Frontiers Media S.A. 2014-05-21 /pmc/articles/PMC4033128/ /pubmed/24904397 http://dx.doi.org/10.3389/fninf.2014.00051 Text en Copyright © 2014 Zaldivar and Krichmar. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Zaldivar, Andrew
Krichmar, Jeffrey L.
Allen Brain Atlas-Driven Visualizations: a web-based gene expression energy visualization tool
title Allen Brain Atlas-Driven Visualizations: a web-based gene expression energy visualization tool
title_full Allen Brain Atlas-Driven Visualizations: a web-based gene expression energy visualization tool
title_fullStr Allen Brain Atlas-Driven Visualizations: a web-based gene expression energy visualization tool
title_full_unstemmed Allen Brain Atlas-Driven Visualizations: a web-based gene expression energy visualization tool
title_short Allen Brain Atlas-Driven Visualizations: a web-based gene expression energy visualization tool
title_sort allen brain atlas-driven visualizations: a web-based gene expression energy visualization tool
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033128/
https://www.ncbi.nlm.nih.gov/pubmed/24904397
http://dx.doi.org/10.3389/fninf.2014.00051
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