Deadenylation of mRNA by the CCR4–NOT complex in Drosophila: molecular and developmental aspects

Controlled shortening of the poly(A) tail of mRNAs is the first step in eukaryotic mRNA decay and can also be used for translational inactivation of mRNAs. The CCR4–NOT complex is the most important among a small number of deadenylases, enzymes catalyzing poly(A) tail shortening. Rates of poly(A) sh...

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Autores principales: Temme, Claudia, Simonelig, Martine, Wahle, Elmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033318/
https://www.ncbi.nlm.nih.gov/pubmed/24904643
http://dx.doi.org/10.3389/fgene.2014.00143
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author Temme, Claudia
Simonelig, Martine
Wahle, Elmar
author_facet Temme, Claudia
Simonelig, Martine
Wahle, Elmar
author_sort Temme, Claudia
collection PubMed
description Controlled shortening of the poly(A) tail of mRNAs is the first step in eukaryotic mRNA decay and can also be used for translational inactivation of mRNAs. The CCR4–NOT complex is the most important among a small number of deadenylases, enzymes catalyzing poly(A) tail shortening. Rates of poly(A) shortening differ between mRNAs as the CCR4–NOT complex is recruited to specific mRNAs by means of either sequence-specific RNA binding proteins or miRNAs. This review summarizes our current knowledge concerning the subunit composition and deadenylation activity of the Drosophila CCR4–NOT complex and the mechanisms by which the complex is recruited to particular mRNAs. We discuss genetic data implicating the complex in the regulation of specific mRNAs, in particular in the context of development.
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spelling pubmed-40333182014-06-05 Deadenylation of mRNA by the CCR4–NOT complex in Drosophila: molecular and developmental aspects Temme, Claudia Simonelig, Martine Wahle, Elmar Front Genet Genetics Controlled shortening of the poly(A) tail of mRNAs is the first step in eukaryotic mRNA decay and can also be used for translational inactivation of mRNAs. The CCR4–NOT complex is the most important among a small number of deadenylases, enzymes catalyzing poly(A) tail shortening. Rates of poly(A) shortening differ between mRNAs as the CCR4–NOT complex is recruited to specific mRNAs by means of either sequence-specific RNA binding proteins or miRNAs. This review summarizes our current knowledge concerning the subunit composition and deadenylation activity of the Drosophila CCR4–NOT complex and the mechanisms by which the complex is recruited to particular mRNAs. We discuss genetic data implicating the complex in the regulation of specific mRNAs, in particular in the context of development. Frontiers Media S.A. 2014-05-26 /pmc/articles/PMC4033318/ /pubmed/24904643 http://dx.doi.org/10.3389/fgene.2014.00143 Text en Copyright © 2014 Temme, Simonelig and Wahle. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Temme, Claudia
Simonelig, Martine
Wahle, Elmar
Deadenylation of mRNA by the CCR4–NOT complex in Drosophila: molecular and developmental aspects
title Deadenylation of mRNA by the CCR4–NOT complex in Drosophila: molecular and developmental aspects
title_full Deadenylation of mRNA by the CCR4–NOT complex in Drosophila: molecular and developmental aspects
title_fullStr Deadenylation of mRNA by the CCR4–NOT complex in Drosophila: molecular and developmental aspects
title_full_unstemmed Deadenylation of mRNA by the CCR4–NOT complex in Drosophila: molecular and developmental aspects
title_short Deadenylation of mRNA by the CCR4–NOT complex in Drosophila: molecular and developmental aspects
title_sort deadenylation of mrna by the ccr4–not complex in drosophila: molecular and developmental aspects
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033318/
https://www.ncbi.nlm.nih.gov/pubmed/24904643
http://dx.doi.org/10.3389/fgene.2014.00143
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