Cargando…
JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diabetic Rats
We investigated the effects of JTT-130 on glucose and lipid metabolism independent of the suppression of feeding by comparing with pair-fed animals. Male Zucker diabetic fatty (ZDF) rats were divided into control, JTT-130 treatment, and pair-fed groups. The rats were fed with a regular powdered diet...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033514/ https://www.ncbi.nlm.nih.gov/pubmed/24895641 http://dx.doi.org/10.1155/2014/803832 |
_version_ | 1782317831240548352 |
---|---|
author | Sakata, Shohei Ito, Makoto Mera, Yasuko Sasase, Tomohiko Yamamoto, Hiromi Kakutani, Makoto Ohta, Takeshi |
author_facet | Sakata, Shohei Ito, Makoto Mera, Yasuko Sasase, Tomohiko Yamamoto, Hiromi Kakutani, Makoto Ohta, Takeshi |
author_sort | Sakata, Shohei |
collection | PubMed |
description | We investigated the effects of JTT-130 on glucose and lipid metabolism independent of the suppression of feeding by comparing with pair-fed animals. Male Zucker diabetic fatty (ZDF) rats were divided into control, JTT-130 treatment, and pair-fed groups. The rats were fed with a regular powdered diet with or without JTT-130 as a food admixture for 6 weeks. We compared the effects on glucose and lipid metabolism in JTT-130 treatment group with those in pair-fed group. Results. Hyperglycemia in ZDF rats was prevented in both JTT-130 treatment and pair-fed groups, but the prevention in pair-fed group became poor with time. Moreover, reduction in plasma cholesterol levels was observed only in JTT-130 treatment group. JTT-130 treatment group showed improved glucose tolerance at 5 weeks after treatment and significant elevation of portal glucagon-like peptide-1 (GLP-1) levels. The hepatic lipid content in JTT-130 treatment group was decreased as compared with pair-fed group. Furthermore, pancreatic protection effects, such as an increase in pancreatic weight and an elevation of insulin-positive area in islets, were observed after JTT-130 treatment. Conclusions. JTT-130 improves hyperglycemia and dyslipidemia via a mechanism independent of suppression of food intake, which is ascribed to an enhancement of GLP-1 secretion and a reduction of lipotoxicity. |
format | Online Article Text |
id | pubmed-4033514 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40335142014-06-03 JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diabetic Rats Sakata, Shohei Ito, Makoto Mera, Yasuko Sasase, Tomohiko Yamamoto, Hiromi Kakutani, Makoto Ohta, Takeshi J Diabetes Res Research Article We investigated the effects of JTT-130 on glucose and lipid metabolism independent of the suppression of feeding by comparing with pair-fed animals. Male Zucker diabetic fatty (ZDF) rats were divided into control, JTT-130 treatment, and pair-fed groups. The rats were fed with a regular powdered diet with or without JTT-130 as a food admixture for 6 weeks. We compared the effects on glucose and lipid metabolism in JTT-130 treatment group with those in pair-fed group. Results. Hyperglycemia in ZDF rats was prevented in both JTT-130 treatment and pair-fed groups, but the prevention in pair-fed group became poor with time. Moreover, reduction in plasma cholesterol levels was observed only in JTT-130 treatment group. JTT-130 treatment group showed improved glucose tolerance at 5 weeks after treatment and significant elevation of portal glucagon-like peptide-1 (GLP-1) levels. The hepatic lipid content in JTT-130 treatment group was decreased as compared with pair-fed group. Furthermore, pancreatic protection effects, such as an increase in pancreatic weight and an elevation of insulin-positive area in islets, were observed after JTT-130 treatment. Conclusions. JTT-130 improves hyperglycemia and dyslipidemia via a mechanism independent of suppression of food intake, which is ascribed to an enhancement of GLP-1 secretion and a reduction of lipotoxicity. Hindawi Publishing Corporation 2014 2014-05-07 /pmc/articles/PMC4033514/ /pubmed/24895641 http://dx.doi.org/10.1155/2014/803832 Text en Copyright © 2014 Shohei Sakata et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Sakata, Shohei Ito, Makoto Mera, Yasuko Sasase, Tomohiko Yamamoto, Hiromi Kakutani, Makoto Ohta, Takeshi JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diabetic Rats |
title | JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diabetic Rats |
title_full | JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diabetic Rats |
title_fullStr | JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diabetic Rats |
title_full_unstemmed | JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diabetic Rats |
title_short | JTT-130, a Novel Intestine-Specific Inhibitor of Microsomal Triglyceride Transfer Protein, Improves Hyperglycemia and Dyslipidemia Independent of Suppression of Food Intake in Diabetic Rats |
title_sort | jtt-130, a novel intestine-specific inhibitor of microsomal triglyceride transfer protein, improves hyperglycemia and dyslipidemia independent of suppression of food intake in diabetic rats |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033514/ https://www.ncbi.nlm.nih.gov/pubmed/24895641 http://dx.doi.org/10.1155/2014/803832 |
work_keys_str_mv | AT sakatashohei jtt130anovelintestinespecificinhibitorofmicrosomaltriglyceridetransferproteinimproveshyperglycemiaanddyslipidemiaindependentofsuppressionoffoodintakeindiabeticrats AT itomakoto jtt130anovelintestinespecificinhibitorofmicrosomaltriglyceridetransferproteinimproveshyperglycemiaanddyslipidemiaindependentofsuppressionoffoodintakeindiabeticrats AT merayasuko jtt130anovelintestinespecificinhibitorofmicrosomaltriglyceridetransferproteinimproveshyperglycemiaanddyslipidemiaindependentofsuppressionoffoodintakeindiabeticrats AT sasasetomohiko jtt130anovelintestinespecificinhibitorofmicrosomaltriglyceridetransferproteinimproveshyperglycemiaanddyslipidemiaindependentofsuppressionoffoodintakeindiabeticrats AT yamamotohiromi jtt130anovelintestinespecificinhibitorofmicrosomaltriglyceridetransferproteinimproveshyperglycemiaanddyslipidemiaindependentofsuppressionoffoodintakeindiabeticrats AT kakutanimakoto jtt130anovelintestinespecificinhibitorofmicrosomaltriglyceridetransferproteinimproveshyperglycemiaanddyslipidemiaindependentofsuppressionoffoodintakeindiabeticrats AT ohtatakeshi jtt130anovelintestinespecificinhibitorofmicrosomaltriglyceridetransferproteinimproveshyperglycemiaanddyslipidemiaindependentofsuppressionoffoodintakeindiabeticrats |