NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome

T cell stimulation requires the input and integration of external signals. Signaling through the T cell receptor (TCR) is known to induce formation of the membrane-tethered CBM complex, comprising CARMA1, BCL10, and MALT1, which is required for TCR-mediated NF-κB activation. TCR signaling has been s...

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Detalles Bibliográficos
Autores principales: Shin, Hyun Mu, Tilahun, Mulualem E., Cho, Ok Hyun, Chandiran, Karthik, Kuksin, Christina Arieta, Keerthivasan, Shilpa, Fauq, Abdul H., Golde, Todd E., Miele, Lucio, Thome, Margot, Osborne, Barbara A., Minter, Lisa M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033603/
https://www.ncbi.nlm.nih.gov/pubmed/24904593
http://dx.doi.org/10.3389/fimmu.2014.00249

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