Insights into the Mechanism of Deubiquitination by JAMM Deubiquitinases from Cocrystal Structures of the Enzyme with the Substrate and Product

[Image: see text] AMSH, a conserved zinc metallo deubiquitinase, controls downregulation and degradation of cell-surface receptors mediated by the endosomal sorting complexes required for transport (ESCRT) machinery. It displays high specificity toward the Lys63-linked polyubiquitin chain, which is...

Descripción completa

Detalles Bibliográficos
Autores principales: Shrestha, Rashmi K., Ronau, Judith A., Davies, Christopher W., Guenette, Robert G., Strieter, Eric R., Paul, Lake N., Das, Chittaranjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033627/
https://www.ncbi.nlm.nih.gov/pubmed/24787148
http://dx.doi.org/10.1021/bi5003162

Ejemplares similares

Ejemplares similares