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Mutagenic Potential of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Bypass Catalyzed by Human Y-Family DNA Polymerases

[Image: see text] One of the most common lesions induced by oxidative DNA damage is 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG). Replicative DNA polymerases poorly traverse this highly mutagenic lesion, suggesting that the replication fork may switch to a polymerase specialized for translesion DNA...

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Detalles Bibliográficos
Autores principales:	Taggart, David J., Fredrickson, Saul W., Gadkari, Varun V., Suo, Zucai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033635/ https://www.ncbi.nlm.nih.gov/pubmed/24779885 http://dx.doi.org/10.1021/tx500088e

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