Dual C–H Functionalization of N-Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach

[Image: see text] Iminium ions generated in situ via copper(I) bromide catalyzed oxidation of N-aryl amines readily undergo [4 + 2] cycloadditions with a range of dienophiles. This method involves the functionalization of both a C(sp(3))–H and a C(sp(2))–H bond and enables the rapid construction of...

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Autores principales: Min, Chang, Sanchawala, Abbas, Seidel, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033637/
https://www.ncbi.nlm.nih.gov/pubmed/24786302
http://dx.doi.org/10.1021/ol501073f
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author Min, Chang
Sanchawala, Abbas
Seidel, Daniel
author_facet Min, Chang
Sanchawala, Abbas
Seidel, Daniel
author_sort Min, Chang
collection PubMed
description [Image: see text] Iminium ions generated in situ via copper(I) bromide catalyzed oxidation of N-aryl amines readily undergo [4 + 2] cycloadditions with a range of dienophiles. This method involves the functionalization of both a C(sp(3))–H and a C(sp(2))–H bond and enables the rapid construction of polycyclic amines under relatively mild conditions.
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spelling pubmed-40336372015-05-01 Dual C–H Functionalization of N-Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach Min, Chang Sanchawala, Abbas Seidel, Daniel Org Lett [Image: see text] Iminium ions generated in situ via copper(I) bromide catalyzed oxidation of N-aryl amines readily undergo [4 + 2] cycloadditions with a range of dienophiles. This method involves the functionalization of both a C(sp(3))–H and a C(sp(2))–H bond and enables the rapid construction of polycyclic amines under relatively mild conditions. American Chemical Society 2014-05-01 2014-05-16 /pmc/articles/PMC4033637/ /pubmed/24786302 http://dx.doi.org/10.1021/ol501073f Text en Copyright © 2014 American Chemical Society
spellingShingle Min, Chang
Sanchawala, Abbas
Seidel, Daniel
Dual C–H Functionalization of N-Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach
title Dual C–H Functionalization of N-Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach
title_full Dual C–H Functionalization of N-Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach
title_fullStr Dual C–H Functionalization of N-Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach
title_full_unstemmed Dual C–H Functionalization of N-Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach
title_short Dual C–H Functionalization of N-Aryl Amines: Synthesis of Polycyclic Amines via an Oxidative Povarov Approach
title_sort dual c–h functionalization of n-aryl amines: synthesis of polycyclic amines via an oxidative povarov approach
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033637/
https://www.ncbi.nlm.nih.gov/pubmed/24786302
http://dx.doi.org/10.1021/ol501073f
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AT seideldaniel dualchfunctionalizationofnarylaminessynthesisofpolycyclicaminesviaanoxidativepovarovapproach

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