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Entrapment of an EGFR inhibitor into nanostructured lipid carriers (NLC) improves its antitumor activity against human hepatocarcinoma cells

BACKGROUND: In hepatocellular carcinoma (HCC), different signaling pathways are de-regulated, and among them, the expression of the epidermal growth factor receptor (EGFR). Tyrphostin AG-1478 is a lipophilic low molecular weight inhibitor of EGFR, preferentially acting on liver tumor cells. In order...

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Detalles Bibliográficos
Autores principales:	Bondì, Maria Luisa, Azzolina, Antonina, Craparo, Emanuela Fabiola, Botto, Chiara, Amore, Erika, Giammona, Gaetano, Cervello, Melchiorre
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033685/ https://www.ncbi.nlm.nih.gov/pubmed/24886097 http://dx.doi.org/10.1186/1477-3155-12-21

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