Deregulation of Interferon Signaling in Malignant Cells

Interferons (IFNs) are a family of cytokines with potent antiproliferative, antiviral, and immunomodulatory properties. Much has been learned about IFNs and IFN-activated signaling cascades over the last 50 years. Due to their potent antitumor effects in vitro and in vivo, recombinant IFNs have been...

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Autores principales: Katsoulidis, Efstratios, Kaur, Surinder, Platanias, Leonidas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033917/
https://www.ncbi.nlm.nih.gov/pubmed/27713259
http://dx.doi.org/10.3390/ph3020406
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author Katsoulidis, Efstratios
Kaur, Surinder
Platanias, Leonidas C.
author_facet Katsoulidis, Efstratios
Kaur, Surinder
Platanias, Leonidas C.
author_sort Katsoulidis, Efstratios
collection PubMed
description Interferons (IFNs) are a family of cytokines with potent antiproliferative, antiviral, and immunomodulatory properties. Much has been learned about IFNs and IFN-activated signaling cascades over the last 50 years. Due to their potent antitumor effects in vitro and in vivo, recombinant IFNs have been used extensively over the years, alone or in combination with other drugs, for the treatment of various malignancies. This review summarizes the current knowledge on IFN signaling components and pathways that are deregulated in human malignancies. The relevance of deregulation of IFN signaling pathways in defective innate immune surveillance and tumorigenesis are discussed.
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spelling pubmed-40339172014-05-27 Deregulation of Interferon Signaling in Malignant Cells Katsoulidis, Efstratios Kaur, Surinder Platanias, Leonidas C. Pharmaceuticals (Basel) Review Interferons (IFNs) are a family of cytokines with potent antiproliferative, antiviral, and immunomodulatory properties. Much has been learned about IFNs and IFN-activated signaling cascades over the last 50 years. Due to their potent antitumor effects in vitro and in vivo, recombinant IFNs have been used extensively over the years, alone or in combination with other drugs, for the treatment of various malignancies. This review summarizes the current knowledge on IFN signaling components and pathways that are deregulated in human malignancies. The relevance of deregulation of IFN signaling pathways in defective innate immune surveillance and tumorigenesis are discussed. Molecular Diversity Preservation International 2010-02-04 /pmc/articles/PMC4033917/ /pubmed/27713259 http://dx.doi.org/10.3390/ph3020406 Text en © 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Katsoulidis, Efstratios
Kaur, Surinder
Platanias, Leonidas C.
Deregulation of Interferon Signaling in Malignant Cells
title Deregulation of Interferon Signaling in Malignant Cells
title_full Deregulation of Interferon Signaling in Malignant Cells
title_fullStr Deregulation of Interferon Signaling in Malignant Cells
title_full_unstemmed Deregulation of Interferon Signaling in Malignant Cells
title_short Deregulation of Interferon Signaling in Malignant Cells
title_sort deregulation of interferon signaling in malignant cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033917/
https://www.ncbi.nlm.nih.gov/pubmed/27713259
http://dx.doi.org/10.3390/ph3020406
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