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Rational Polytherapy with Antiepileptic Drugs

Approximately 30–40% of patients do not achieve seizure control with a single antiepileptic drug (AED). With the advent of multiple AEDs in the past 15 years, rational polytherapy, the goal of finding combinations of AEDs that have favorable characteristics, has become of greater importance. We revi...

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Detalles Bibliográficos
Autores principales: Lee, Jong Woo, Dworetzky, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033928/
https://www.ncbi.nlm.nih.gov/pubmed/27713357
http://dx.doi.org/10.3390/ph3082362
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author Lee, Jong Woo
Dworetzky, Barbara
author_facet Lee, Jong Woo
Dworetzky, Barbara
author_sort Lee, Jong Woo
collection PubMed
description Approximately 30–40% of patients do not achieve seizure control with a single antiepileptic drug (AED). With the advent of multiple AEDs in the past 15 years, rational polytherapy, the goal of finding combinations of AEDs that have favorable characteristics, has become of greater importance. We review the theoretical considerations based on AED mechanism of action, animal models, human studies in this field, and the challenges in finding such optimal combinations. Several case scenarios are presented, illustrating examples of rational polytherapy.
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spelling pubmed-40339282014-05-27 Rational Polytherapy with Antiepileptic Drugs Lee, Jong Woo Dworetzky, Barbara Pharmaceuticals (Basel) Review Approximately 30–40% of patients do not achieve seizure control with a single antiepileptic drug (AED). With the advent of multiple AEDs in the past 15 years, rational polytherapy, the goal of finding combinations of AEDs that have favorable characteristics, has become of greater importance. We review the theoretical considerations based on AED mechanism of action, animal models, human studies in this field, and the challenges in finding such optimal combinations. Several case scenarios are presented, illustrating examples of rational polytherapy. MDPI 2010-07-26 /pmc/articles/PMC4033928/ /pubmed/27713357 http://dx.doi.org/10.3390/ph3082362 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Lee, Jong Woo
Dworetzky, Barbara
Rational Polytherapy with Antiepileptic Drugs
title Rational Polytherapy with Antiepileptic Drugs
title_full Rational Polytherapy with Antiepileptic Drugs
title_fullStr Rational Polytherapy with Antiepileptic Drugs
title_full_unstemmed Rational Polytherapy with Antiepileptic Drugs
title_short Rational Polytherapy with Antiepileptic Drugs
title_sort rational polytherapy with antiepileptic drugs
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033928/
https://www.ncbi.nlm.nih.gov/pubmed/27713357
http://dx.doi.org/10.3390/ph3082362
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