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Rational Polytherapy with Antiepileptic Drugs
Approximately 30–40% of patients do not achieve seizure control with a single antiepileptic drug (AED). With the advent of multiple AEDs in the past 15 years, rational polytherapy, the goal of finding combinations of AEDs that have favorable characteristics, has become of greater importance. We revi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033928/ https://www.ncbi.nlm.nih.gov/pubmed/27713357 http://dx.doi.org/10.3390/ph3082362 |
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author | Lee, Jong Woo Dworetzky, Barbara |
author_facet | Lee, Jong Woo Dworetzky, Barbara |
author_sort | Lee, Jong Woo |
collection | PubMed |
description | Approximately 30–40% of patients do not achieve seizure control with a single antiepileptic drug (AED). With the advent of multiple AEDs in the past 15 years, rational polytherapy, the goal of finding combinations of AEDs that have favorable characteristics, has become of greater importance. We review the theoretical considerations based on AED mechanism of action, animal models, human studies in this field, and the challenges in finding such optimal combinations. Several case scenarios are presented, illustrating examples of rational polytherapy. |
format | Online Article Text |
id | pubmed-4033928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40339282014-05-27 Rational Polytherapy with Antiepileptic Drugs Lee, Jong Woo Dworetzky, Barbara Pharmaceuticals (Basel) Review Approximately 30–40% of patients do not achieve seizure control with a single antiepileptic drug (AED). With the advent of multiple AEDs in the past 15 years, rational polytherapy, the goal of finding combinations of AEDs that have favorable characteristics, has become of greater importance. We review the theoretical considerations based on AED mechanism of action, animal models, human studies in this field, and the challenges in finding such optimal combinations. Several case scenarios are presented, illustrating examples of rational polytherapy. MDPI 2010-07-26 /pmc/articles/PMC4033928/ /pubmed/27713357 http://dx.doi.org/10.3390/ph3082362 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an Open Access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Lee, Jong Woo Dworetzky, Barbara Rational Polytherapy with Antiepileptic Drugs |
title | Rational Polytherapy with Antiepileptic Drugs |
title_full | Rational Polytherapy with Antiepileptic Drugs |
title_fullStr | Rational Polytherapy with Antiepileptic Drugs |
title_full_unstemmed | Rational Polytherapy with Antiepileptic Drugs |
title_short | Rational Polytherapy with Antiepileptic Drugs |
title_sort | rational polytherapy with antiepileptic drugs |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033928/ https://www.ncbi.nlm.nih.gov/pubmed/27713357 http://dx.doi.org/10.3390/ph3082362 |
work_keys_str_mv | AT leejongwoo rationalpolytherapywithantiepilepticdrugs AT dworetzkybarbara rationalpolytherapywithantiepilepticdrugs |