Cargando…

Use of p38 MAPK Inhibitors for the Treatment of Werner Syndrome

Werner syndrome provides a convincing model for aspects of the normal ageing phenotype and may provide a suitable model for therapeutic interventions designed to combat the ageing process. Cultured primary fibroblast cells from Werner syndrome patients provide a powerful model system to study the li...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bagley, Mark C., Davis, Terence, Murziani, Paola G. S., Widdowson, Caroline S., Kipling, David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033955/ https://www.ncbi.nlm.nih.gov/pubmed/27713332 http://dx.doi.org/10.3390/ph3061842

Ejemplares similares

Evaluating the Role of p38 MAPK in the Accelerated Cell Senescence of Werner Syndrome Fibroblasts
por: Davis, Terence, et al.
Publicado: (2016)

Investigating the role of c-Jun N-terminal kinases in the proliferation of Werner syndrome fibroblasts using diaminopyridine inhibitors
por: Davis, Terence, et al.
Publicado: (2011)

Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells
por: Bagley, Mark C., et al.
Publicado: (2015)

The effect of small-molecule inhibition of MAPKAPK2 on cell ageing phenotypes of fibroblasts from human Werner syndrome
por: Davis, Terence, et al.
Publicado: (2013)

p38 (MAPK) stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes
por: Tivey, Hannah S. E., et al.
Publicado: (2012)

Small Molecule Inhibition of p38 MAP Kinase Extends the Replicative Life Span of Human ATR-Seckel Syndrome Fibroblasts
por: Tivey, Hannah S. E., et al.
Publicado: (2013)

Nijmegen breakage syndrome fibroblasts expressing the C-terminal truncated NBN(p70) protein undergo p38/MK2-dependent premature senescence
por: Davis, Terence, et al.
Publicado: (2014)

Activation of p38 MAP kinase and stress signalling in fibroblasts from the progeroid Rothmund–Thomson syndrome
por: Davis, Terence, et al.
Publicado: (2012)

Inhibition of LPS-Induced Activation of Coagulation by p38 MAPK Inhibitor
por: Koch, Lutz, et al.
Publicado: (2012)

p38 MAPK in MDS
por: Gañán‐Gómez, Irene, et al.
Publicado: (2015)

Suppression of the senescence-associated secretory phenotype (SASP) in human fibroblasts using small molecule inhibitors of p38 MAP kinase and MK2
por: Alimbetov, Dauren, et al.
Publicado: (2015)

Werner Syndrome
por: Chen, Lishan, et al.
Publicado: (2002)

Nuclear Localization of p38 MAPK in Response to DNA Damage
por: Wood, C. David, et al.
Publicado: (2009)

New Insights into the p38γ and p38δ MAPK Pathways
por: Risco, Ana, et al.
Publicado: (2012)

p38γ and p38δ Mitogen Activated Protein Kinases (MAPKs), New Stars in the MAPK Galaxy
por: Escós, Alejandra, et al.
Publicado: (2016)

p38 MAPK Signaling in Osteoblast Differentiation
por: Rodríguez-Carballo, Eddie, et al.
Publicado: (2016)

p38 MAPK in cardioprotection – are we there yet?
por: Martin, E D, et al.
Publicado: (2015)

P38 MAPK and Radiotherapy: Foes or Friends?
por: García-Flores, Natalia, et al.
Publicado: (2023)

Small molecule targeting of the p38/Mk2 stress signaling pathways to improve cancer treatment
por: Alimbetov, D., et al.
Publicado: (2023)

p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics
por: Ahmadi, Ali, et al.
Publicado: (2023)

Design, Synthesis, and Biological Evaluation of Tetra-Substituted Thiophenes as Inhibitors of p38α MAPK
por: Vinh, Natalie B, et al.
Publicado: (2015)

Werner's Syndrome (Progeria in the Adult)
por: Grant, Alan P.
Publicado: (1957)

Management of cataract in Werner syndrome
por: Kusumesh, Rakhi, et al.
Publicado: (2018)

Oxidative stress and antioxidant response in fibroblasts from Werner and Atypical Werner Syndromes
por: Seco-Cervera, Marta, et al.
Publicado: (2014)

p38 MAPK, microglial signaling, and neuropathic pain
por: Ji, Ru-Rong, et al.
Publicado: (2007)

The Role of p38 MAPK in the Development of Diabetic Cardiomyopathy
por: Wang, Shudong, et al.
Publicado: (2016)

Cancer suppression by systemic inactivation of p38MAPK
por: Brichkina, Anna, et al.
Publicado: (2017)

Involvement of p38 MAPK in Synaptic Function and Dysfunction
por: Falcicchia, Chiara, et al.
Publicado: (2020)

Crosstalk between p38 MAPK and GR Signaling
por: Zeyen, Lisa, et al.
Publicado: (2022)

p38 MAPK regulates the Wnt inhibitor Dickkopf-1 in osteotropic prostate cancer cells
por: Browne, A J, et al.
Publicado: (2016)

Effect of a p38 MAPK inhibitor on FFA-induced hepatic insulin resistance in vivo
por: Pereira, S, et al.
Publicado: (2016)

Oral and inhaled p38 MAPK inhibitors: effects on inhaled LPS challenge in healthy subjects
por: Singh, Dave, et al.
Publicado: (2015)

In Silico Screening and In Vitro Activity Measurement of Javamide Analogues as Potential p38 MAPK Inhibitors
por: Park, Jae B.
Publicado: (2017)

Effect of the p38 MAPK inhibitor doramapimod on the systemic inflammatory response to intravenous lipopolysaccharide in horses
por: Bauquier, Jennifer, et al.
Publicado: (2020)

Insights from the molecular docking and simulation analysis of P38 MAPK phytochemical inhibitor complexes
por: Prasada Rao, Chennu MM, et al.
Publicado: (2023)

The p38 MAPK Signaling Activation in Colorectal Cancer upon Therapeutic Treatments
por: Pranteda, Angelina, et al.
Publicado: (2020)

RNA-seq Characterization of Melanoma Phenotype Switch in 3D Collagen after p38 MAPK Inhibitor Treatment
por: Čermák, Vladimír, et al.
Publicado: (2021)

Do you know this syndrome? Werner syndrome
por: Bilgiç, Özlem
Publicado: (2017)

Recent Advances in Understanding Werner Syndrome
por: Shamanna, Raghavendra A., et al.
Publicado: (2017)

Werner Syndrome Protein and DNA Replication
por: Mukherjee, Shibani, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_cspqucmbenfofgu8i2f7slssmu