Cargando…

Platelet-Derived Growth Factor (PDGF)/PDGF Receptors (PDGFR) Axis as Target for Antitumor and Antiangiogenic Therapy

Angiogenesis in normal and pathological conditions is a multi-step process governed by positive and negative endogenous regulators. Many growth factors are involved in different steps of angiogenesis, like vascular endothelial growth factors (VEGF), fibroblast growth factor (FGF)-2 or platelet-deriv...

Descripción completa

Detalles Bibliográficos
Autores principales:	Raica, Marius, Cimpean, Anca Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033970/ https://www.ncbi.nlm.nih.gov/pubmed/27713269 http://dx.doi.org/10.3390/ph3030572

Ejemplares similares

PDGF/PDGFR effects in osteosarcoma and the “add-on” strategy
por: Xu, Jie, et al.
Publicado: (2018)

PDGF/PDGFR: A Possible Molecular Target in Scleroderma Fibrosis
por: Paolini, Chiara, et al.
Publicado: (2022)

Targeting the PDGF-B/PDGFR-β Interface with Destruxin A5 to Selectively Block PDGF-BB/PDGFR-ββ Signaling and Attenuate Liver Fibrosis
por: Wang, Xingqi, et al.
Publicado: (2016)

Coexpression of Platelet‐derived Growth Factor (PDGF) A‐Chain and PDGF Receptor Genes in Human Gastric Carcinomas
por: Tsuda, Toshitaka, et al.
Publicado: (1989)

PDGF and PDGF receptors in glioma
por: Nazarenko, Inga, et al.
Publicado: (2012)

Targeting PDGF‐mediated recruitment of pericytes blocks vascular mimicry and tumor growth
por: Thijssen, Victor LJL, et al.
Publicado: (2018)

Comprehensive Dissection of PDGF-PDGFR Signaling Pathways in PDGFR Genetically Defined Cells
por: Wu, Erxi, et al.
Publicado: (2008)

PDGFR in PDGF-BB/PDGFR Signaling Pathway Does Orchestrates Osteogenesis in a Temporal Manner
por: Wang, Fangqian, et al.
Publicado: (2023)

A fibronectin peptide redirects PDGF-BB/PDGFR complexes to macropinocytosis-like internalization and augments PDGF-BB survival signals
por: Zhu, Jia, et al.
Publicado: (2013)

Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression
por: Tsioumpekou, Maria, et al.
Publicado: (2020)

Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression: Erratum
por: Tsioumpekou, Maria, et al.
Publicado: (2020)

Molecular Characterization of PDGFR-α/PDGF-A and c-KIT/SCF in Gliosarcomas
por: Reis, Rui M., et al.
Publicado: (2005)

Preclinical toxicological assessment of a novel monoclonal antibody targeting human platelet-derived growth factor CC (PDGF-CC) in PDGF-CC(hum) mice
por: Zeitelhofer, Manuel, et al.
Publicado: (2018)

Clinicopathological significance of platelet-derived growth factor (PDGF)-B and vascular endothelial growth factor-A expression, PDGF receptor-β phosphorylation, and microvessel density in gastric cancer
por: Suzuki, Shioto, et al.
Publicado: (2010)

Development of monoclonal anti-PDGF-CC antibodies as tools for investigating human tissue expression and for blocking PDGF-CC induced PDGFRα signalling in vivo
por: Li, Hong, et al.
Publicado: (2018)

Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF beta-receptor
Publicado: (1991)

Arterial smooth muscle cells express platelet-derived growth factor (PDGF) A chain mRNA, secrete a PDGF-like mitogen, and bind exogenous PDGF in a phenotype- and growth state-dependent manner
Publicado: (1988)

Platelet-derived growth factors induced lymphangiogenesis: evidence, unanswered questions and upcoming challenges
por: Jitariu, Andreea Adriana, et al.
Publicado: (2015)

Osteoclasts Control Osteoblast Chemotaxis via PDGF-BB/PDGF Receptor Beta Signaling
por: Sanchez-Fernandez, Maria Arantzazu, et al.
Publicado: (2008)

PDGF-BB modulates endothelial proliferation and angiogenesis in vitro via PDGF beta-receptors
Publicado: (1994)

Development of renal renin-expressing cells does not involve PDGF-B-PDGFR-β signaling
por: Neubauer, Bjoern, et al.
Publicado: (2013)

PDGF-AA and PDGF-BB biosynthesis: proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly
Publicado: (1992)

Endothelial Progenitor Cells Induce a Phenotype Shift in Differentiated Endothelial Cells towards PDGF/PDGFRβ Axis-Mediated Angiogenesis
por: Wyler von Ballmoos, Moritz, et al.
Publicado: (2010)

Pericyte-specific expression of PDGF beta receptor in mouse models with normal and deficient PDGF beta receptor signaling
por: Winkler, Ethan A, et al.
Publicado: (2010)

Stimulation of beta1 integrins on fibroblasts induces PDGF independent tyrosine phosphorylation of PDGF beta-receptors
Publicado: (1996)

Accumulation of PDGF B and cell-binding forms of PDGF A in the extracellular matrix
Publicado: (1993)

Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an Immunoregulatory Factor Mediating Airway Remodeling and Possible Pharmacological Target
por: Kardas, Grzegorz, et al.
Publicado: (2020)

Leydig Cell Loss and Spermatogenic Arrest in Platelet-Derived Growth Factor (Pdgf)-a–Deficient Mice
por: Gnessi, Lucio, et al.
Publicado: (2000)

Lateral Flow Aptasensor for Simultaneous Detection of Platelet-Derived Growth Factor-BB (PDGF-BB) and Thrombin
por: Liu, Guodong, et al.
Publicado: (2019)

Membrane-anchored form of v-sis/PDGF-B induces mitogenesis without detectable PDGF receptor autophosphorylation
Publicado: (1991)

A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex
por: Andrae, Johanna, et al.
Publicado: (2016)

Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer’s disease
por: Smyth, Leon C. D., et al.
Publicado: (2022)

PDGF-D−PDGFRβ signaling enhances IL-15–mediated human natural killer cell survival
por: Ma, Shoubao, et al.
Publicado: (2022)

Elevated PDGF‐BB from Bone Impairs Hippocampal Vasculature by Inducing PDGFRβ Shedding from Pericytes
por: Liu, Guanqiao, et al.
Publicado: (2023)

Platelet-derived growth factor (PDGF) cross-signaling via non-corresponding receptors indicates bypassed signaling in colorectal cancer
por: Moench, Romana, et al.
Publicado: (2022)

Targeting the PDGF signaling pathway in tumor treatment
por: Heldin, Carl-Henrik
Publicado: (2013)

Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha
por: Kadrmas, Julie L., et al.
Publicado: (2020)

The role of PDGF in radiation oncology
por: Li, Minglun, et al.
Publicado: (2007)

Autocrine PDGF stimulation in malignancies
por: Heldin, Carl-Henrik
Publicado: (2012)

Rat Hippocampal Neural Stem Cell Modulation Using PDGF, VEGF, PDGF/VEGF, and BDNF
por: Pelegri, Neus Gomila, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ukgssu1q2ml518fbj2g7digpiv