Cargando…

2-Deoxystreptamine Conjugates by Truncation–Derivatization of Neomycin

A small library of truncated neomycin-conjugates is prepared by consecutive removal of 2,6-diaminoglucose rings, oxidation-reductive amination of ribose, oxidation-conjugation of aminopyridine/aminoquinoline and finally dimerization. The dimeric conjugates were evaluated for antibacterial activity w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aslam, M. Waqar, Tabares, Leandro C., Andreoni, Alessio, Canters, Gerard W., Rutjes, Floris P.J.T., van Delft, Floris L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033975/ https://www.ncbi.nlm.nih.gov/pubmed/27713274 http://dx.doi.org/10.3390/ph3030679

Ejemplares similares

Multinuclear Nuclear Magnetic Resonance Spectroscopy Is Used to Determine Rapidly and Accurately the Individual pK(a) Values of 2-Deoxystreptamine, Neamine, Neomycin, Paromomycin, and Streptomycin
por: Alkhzem, Abdulaziz H., et al.
Publicado: (2021)

Strain-Promoted 1,3-Dipolar Cycloaddition of Cycloalkynes and Organic Azides
por: Dommerholt, Jan, et al.
Publicado: (2016)

Synthesis and Antibacterial Activities of Amphiphilic Neomycin B-based Bilipid Conjugates and Fluorinated Neomycin B-based Lipids
por: Bera, Smritilekha, et al.
Publicado: (2012)

Tracking Electrons in Biological Macromolecules: From Ensemble to Single Molecule
por: Tabares, Leandro C., et al.
Publicado: (2014)

Potent inhibition of miR-27a by neomycin–bisbenzimidazole conjugates
por: Nahar, Smita, et al.
Publicado: (2015)

Synthesis of Dihydrouracils Spiro-Fused to Pyrrolidines: Druglike Molecules Based on the 2-Arylethyl Amine Scaffold
por: Blanco-Ania, Daniel, et al.
Publicado: (2010)

An overview of heavy-atom derivatization of protein crystals
por: Pike, Ashley C. W., et al.
Publicado: (2016)

Surface Dependent Dual Recognition of a G-quadruplex DNA With Neomycin-Intercalator Conjugates
por: Ranjan, Nihar, et al.
Publicado: (2020)

Identification and Evaluation of Improved 4′-O-(Alkyl) 4,5-Disubstituted 2-Deoxystreptamines as Next-Generation Aminoglycoside Antibiotics
por: Duscha, Stefan, et al.
Publicado: (2014)

Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes
por: van Diepen, Janna A., et al.
Publicado: (2016)

Parallel G-quadruplex recognition by neomycin
por: Ranjan, Nihar, et al.
Publicado: (2023)

Modification at the 2′-Position of the 4,5-Series of 2-Deoxystreptamine Aminoglycoside Antibiotics To Resist Aminoglycoside Modifying Enzymes and Increase Ribosomal Target Selectivity
por: Sati, Girish C., et al.
Publicado: (2019)

Oligonucleotide Tagging for Copper-Free Click Conjugation
por: Jawalekar, Anup M., et al.
Publicado: (2013)

Non-Genetic Generation of Antibody Conjugates Based on Chemoenzymatic Tyrosine Click Chemistry
por: Bruins, Jorick J., et al.
Publicado: (2021)

The Antibiotic Neomycin Enhances Coxsackievirus Plaque Formation
por: Woods Acevedo, Mikal A., et al.
Publicado: (2019)

Readily Accessible Bicyclononynes for Bioorthogonal Labeling and Three-Dimensional Imaging of Living Cells**
por: Dommerholt, Jan, et al.
Publicado: (2010)

Generation of DAR1 Antibody-Drug Conjugates for Ultrapotent Payloads Using Tailored GlycoConnect Technology
por: de Bever, Laureen, et al.
Publicado: (2023)

Enzyme-Specific Activation versus Leaving Group Ability
por: de Beer, Roseri J A C, et al.
Publicado: (2012)

A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody–Drug Conjugates
por: Verkade, Jorge M. M., et al.
Publicado: (2018)

Mutation K42R in Ribosomal Protein S12 Does Not Affect Susceptibility of Mycobacterium smegmatis 16S rRNA A-Site Mutants to 2-Deoxystreptamines
por: Kalapala, Sarath K., et al.
Publicado: (2010)

On the Interaction of Neomycin with the Slow Vacuolar Channel of Arabidopsis thaliana
por: Scholz-Starke, Joachim, et al.
Publicado: (2006)

Synthesis and Combinational Antibacterial Study of 5″-Modified Neomycin
por: Zhang, Jianjun, et al.
Publicado: (2009)

Effect of the Antibiotic Neomycin on the Toxicity of the Glycoside Vicine in Rats
por: Arbid, Mahmoud S., et al.
Publicado: (2013)

Minocycline Protection of Neomycin Induced Hearing Loss in Gerbils
por: Robinson, Alan M., et al.
Publicado: (2015)

Carbonylonium ions: the onium ions of the carbonyl group
por: Blanco-Ania, Daniel, et al.
Publicado: (2018)

Recent Advances in Bioorthogonal Ligation and Bioconjugation
por: Zielke, Florian M., et al.
Publicado: (2023)

Tetrandrine Prevents Neomycin-Induced Ototoxicity by Promoting Steroid Biosynthesis
por: Zhang, Qilei, et al.
Publicado: (2022)

ortho‐Quinones and Analogues Thereof: Highly Reactive Intermediates for Fast and Selective Biofunctionalization
por: Bruins, Jorick J., et al.
Publicado: (2017)

Correction: Verkade, J.M.M.; et al. A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody–Drug Conjugates. Antibodies 2018, 7, 12
por: Verkade, Jorge M. M., et al.
Publicado: (2018)

Aqueous reductive amination using a dendritic metal catalyst in a dialysis bag
por: Willemsen, Jorgen S, et al.
Publicado: (2013)

Rapid and Complete Surface Modification with Strain‐Promoted Oxidation‐Controlled Cyclooctyne‐1,2‐Quinone Cycloaddition (SPOCQ)
por: Sen, Rickdeb, et al.
Publicado: (2017)

Privileged heterocycles: bioactivity and synthesis of 1,9-diazaspiro[5.5]undecane-containing compounds
por: Blanco-Ania, Daniel, et al.
Publicado: (2017)

Correlation of neomycin, faecal neutral and acid sterols with colon carcinogenesis in rats
por: Panda, S K, et al.
Publicado: (1999)

Autophagy protects auditory hair cells against neomycin-induced damage
por: He, Zuhong, et al.
Publicado: (2017)

Neomycin, polymyxin B, and dexamethasone allergic reactions following periocular surgery
por: Moore, Nicholas A., et al.
Publicado: (2017)

Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage
por: Zhong, Zhenhua, et al.
Publicado: (2020)

Novel pantothenate derivatives for anti-malarial chemotherapy
por: Pett, Helmi E, et al.
Publicado: (2015)

MIL-68 (Ga) for the extraction of derivatized and non-derivatized parabens from healthcare products
por: Pezhhanfar, Sakha, et al.
Publicado: (2023)

Wnt activation protects against neomycin-induced hair cell damage in the mouse cochlea
por: Liu, L, et al.
Publicado: (2016)

Oxidation-Induced “One-Pot” Click Chemistry
por: Albada, Bauke, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_32p8fkss226kli3ib9d4v679ku