Effects of NSAIDs on the Inner Ear: Possible Involvement in Cochlear Protection

Cyclooxygenase and lipoxygenase, two important enzymes involved in arachidonic acid metabolism, are major targets of non-steroidal anti-inflammatory drugs (NSAIDs). Recent investigations suggest that arachidonic cascades and their metabolites may be involved in maintaining inner ear functions. The e...

Descripción completa

Detalles Bibliográficos
Autores principales: Hoshino, Tomofumi, Tabuchi, Keiji, Hara, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033980/
https://www.ncbi.nlm.nih.gov/pubmed/27713301
http://dx.doi.org/10.3390/ph3051286
_version_ 1782317909255651328
author Hoshino, Tomofumi
Tabuchi, Keiji
Hara, Akira
author_facet Hoshino, Tomofumi
Tabuchi, Keiji
Hara, Akira
author_sort Hoshino, Tomofumi
collection PubMed
description Cyclooxygenase and lipoxygenase, two important enzymes involved in arachidonic acid metabolism, are major targets of non-steroidal anti-inflammatory drugs (NSAIDs). Recent investigations suggest that arachidonic cascades and their metabolites may be involved in maintaining inner ear functions. The excessive use of aspirin may cause tinnitus in humans and impairment of the outer hair cell functions in experimental animals. On the other hand, NSAIDs reportedly exhibit protective effects against various kinds of inner ear disorder. The present review summarizes the effects of NSAIDs on cochlear pathophysiology. NSAIDs are a useful ameliorative adjunct in the management of inner ear disorders.
format Online
Article
Text
id pubmed-4033980
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-40339802014-05-27 Effects of NSAIDs on the Inner Ear: Possible Involvement in Cochlear Protection Hoshino, Tomofumi Tabuchi, Keiji Hara, Akira Pharmaceuticals (Basel) Review Cyclooxygenase and lipoxygenase, two important enzymes involved in arachidonic acid metabolism, are major targets of non-steroidal anti-inflammatory drugs (NSAIDs). Recent investigations suggest that arachidonic cascades and their metabolites may be involved in maintaining inner ear functions. The excessive use of aspirin may cause tinnitus in humans and impairment of the outer hair cell functions in experimental animals. On the other hand, NSAIDs reportedly exhibit protective effects against various kinds of inner ear disorder. The present review summarizes the effects of NSAIDs on cochlear pathophysiology. NSAIDs are a useful ameliorative adjunct in the management of inner ear disorders. MDPI 2010-04-27 /pmc/articles/PMC4033980/ /pubmed/27713301 http://dx.doi.org/10.3390/ph3051286 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Hoshino, Tomofumi
Tabuchi, Keiji
Hara, Akira
Effects of NSAIDs on the Inner Ear: Possible Involvement in Cochlear Protection
title Effects of NSAIDs on the Inner Ear: Possible Involvement in Cochlear Protection
title_full Effects of NSAIDs on the Inner Ear: Possible Involvement in Cochlear Protection
title_fullStr Effects of NSAIDs on the Inner Ear: Possible Involvement in Cochlear Protection
title_full_unstemmed Effects of NSAIDs on the Inner Ear: Possible Involvement in Cochlear Protection
title_short Effects of NSAIDs on the Inner Ear: Possible Involvement in Cochlear Protection
title_sort effects of nsaids on the inner ear: possible involvement in cochlear protection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033980/
https://www.ncbi.nlm.nih.gov/pubmed/27713301
http://dx.doi.org/10.3390/ph3051286
work_keys_str_mv AT hoshinotomofumi effectsofnsaidsontheinnerearpossibleinvolvementincochlearprotection
AT tabuchikeiji effectsofnsaidsontheinnerearpossibleinvolvementincochlearprotection
AT haraakira effectsofnsaidsontheinnerearpossibleinvolvementincochlearprotection

Ejemplares similares