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Combining Biofilm-Controlling Compounds and Antibiotics as a Promising New Way to Control Biofilm Infections

Many bacteria grow on surfaces forming biofilms. In this structure, they are well protected and often high dosages of antibiotics cannot clear infectious biofilms. The formation and stabilization of biofilms are mediated by diffusible autoinducers (e.g. N-acyl homoserine lactones, small peptides, fu...

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Detalles Bibliográficos
Autores principales: Estrela, Andréia Bergamo, Abraham, Wolf-Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033987/
https://www.ncbi.nlm.nih.gov/pubmed/27713308
http://dx.doi.org/10.3390/ph3051374
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author Estrela, Andréia Bergamo
Abraham, Wolf-Rainer
author_facet Estrela, Andréia Bergamo
Abraham, Wolf-Rainer
author_sort Estrela, Andréia Bergamo
collection PubMed
description Many bacteria grow on surfaces forming biofilms. In this structure, they are well protected and often high dosages of antibiotics cannot clear infectious biofilms. The formation and stabilization of biofilms are mediated by diffusible autoinducers (e.g. N-acyl homoserine lactones, small peptides, furanosyl borate diester). Metabolites interfering with this process have been identified in plants, animals and microbes, and synthetic analogues are known. Additionally, this seems to be not the only way to control biofilms. Enzymes capable of cleaving essential components of the biofilm matrix, e.g. polysaccharides or extracellular DNA, and thus weakening the biofilm architecture have been identified. Bacteria also have mechanisms to dissolve their biofilms and return to planktonic lifestyle. Only a few compounds responsible for the signalling of these processes are known, but they may open a completely novel line of biofilm control. All these approaches lead to the destruction of the biofilm but not the killing of the pathogens. Therefore, a combination of biofilm-destroying compounds and antibiotics to handle biofilm infections is proposed. In this article, different approaches to combine biofilm-controlling compounds and antibiotics to fight biofilm infections are discussed, as well as the balance between biofilm formation and virulence.
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spelling pubmed-40339872014-05-27 Combining Biofilm-Controlling Compounds and Antibiotics as a Promising New Way to Control Biofilm Infections Estrela, Andréia Bergamo Abraham, Wolf-Rainer Pharmaceuticals (Basel) Review Many bacteria grow on surfaces forming biofilms. In this structure, they are well protected and often high dosages of antibiotics cannot clear infectious biofilms. The formation and stabilization of biofilms are mediated by diffusible autoinducers (e.g. N-acyl homoserine lactones, small peptides, furanosyl borate diester). Metabolites interfering with this process have been identified in plants, animals and microbes, and synthetic analogues are known. Additionally, this seems to be not the only way to control biofilms. Enzymes capable of cleaving essential components of the biofilm matrix, e.g. polysaccharides or extracellular DNA, and thus weakening the biofilm architecture have been identified. Bacteria also have mechanisms to dissolve their biofilms and return to planktonic lifestyle. Only a few compounds responsible for the signalling of these processes are known, but they may open a completely novel line of biofilm control. All these approaches lead to the destruction of the biofilm but not the killing of the pathogens. Therefore, a combination of biofilm-destroying compounds and antibiotics to handle biofilm infections is proposed. In this article, different approaches to combine biofilm-controlling compounds and antibiotics to fight biofilm infections are discussed, as well as the balance between biofilm formation and virulence. MDPI 2010-05-11 /pmc/articles/PMC4033987/ /pubmed/27713308 http://dx.doi.org/10.3390/ph3051374 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Estrela, Andréia Bergamo
Abraham, Wolf-Rainer
Combining Biofilm-Controlling Compounds and Antibiotics as a Promising New Way to Control Biofilm Infections
title Combining Biofilm-Controlling Compounds and Antibiotics as a Promising New Way to Control Biofilm Infections
title_full Combining Biofilm-Controlling Compounds and Antibiotics as a Promising New Way to Control Biofilm Infections
title_fullStr Combining Biofilm-Controlling Compounds and Antibiotics as a Promising New Way to Control Biofilm Infections
title_full_unstemmed Combining Biofilm-Controlling Compounds and Antibiotics as a Promising New Way to Control Biofilm Infections
title_short Combining Biofilm-Controlling Compounds and Antibiotics as a Promising New Way to Control Biofilm Infections
title_sort combining biofilm-controlling compounds and antibiotics as a promising new way to control biofilm infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033987/
https://www.ncbi.nlm.nih.gov/pubmed/27713308
http://dx.doi.org/10.3390/ph3051374
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