Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts – Crucial ‘Human Osteoclastology’

Osteoclasts play a critical role in both normal bone metabolism and bone resorption in the joints of patients with rheumatoid arthritis. It has been reported that non-steroidal anti-inflammatory drugs (NSAIDs) inhibit murine osteoclastogenesis in vitro and murine arthritis models in vivo, but not th...

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Detalles Bibliográficos
Autores principales: Kotake, Shigeru, Yago, Toru, Kawamoto, Manabu, Nanke, Yuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033988/
https://www.ncbi.nlm.nih.gov/pubmed/27713309
http://dx.doi.org/10.3390/ph3051394
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author Kotake, Shigeru
Yago, Toru
Kawamoto, Manabu
Nanke, Yuki
author_facet Kotake, Shigeru
Yago, Toru
Kawamoto, Manabu
Nanke, Yuki
author_sort Kotake, Shigeru
collection PubMed
description Osteoclasts play a critical role in both normal bone metabolism and bone resorption in the joints of patients with rheumatoid arthritis. It has been reported that non-steroidal anti-inflammatory drugs (NSAIDs) inhibit murine osteoclastogenesis in vitro and murine arthritis models in vivo, but not the destruction of joints of patients with rheumatoid arthritis. In the current review article, we review the recent findings in the effect of NSAIDs on the formation and function of human and murine osteoclasts both in vitro and in vivo, underlining the importance of studies using human osteoclasts. Since 2009, we have suggested a novel term ‘human osteoclastology’.
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spelling pubmed-40339882014-05-27 Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts – Crucial ‘Human Osteoclastology’ Kotake, Shigeru Yago, Toru Kawamoto, Manabu Nanke, Yuki Pharmaceuticals (Basel) Review Osteoclasts play a critical role in both normal bone metabolism and bone resorption in the joints of patients with rheumatoid arthritis. It has been reported that non-steroidal anti-inflammatory drugs (NSAIDs) inhibit murine osteoclastogenesis in vitro and murine arthritis models in vivo, but not the destruction of joints of patients with rheumatoid arthritis. In the current review article, we review the recent findings in the effect of NSAIDs on the formation and function of human and murine osteoclasts both in vitro and in vivo, underlining the importance of studies using human osteoclasts. Since 2009, we have suggested a novel term ‘human osteoclastology’. MDPI 2010-05-11 /pmc/articles/PMC4033988/ /pubmed/27713309 http://dx.doi.org/10.3390/ph3051394 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Kotake, Shigeru
Yago, Toru
Kawamoto, Manabu
Nanke, Yuki
Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts – Crucial ‘Human Osteoclastology’
title Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts – Crucial ‘Human Osteoclastology’
title_full Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts – Crucial ‘Human Osteoclastology’
title_fullStr Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts – Crucial ‘Human Osteoclastology’
title_full_unstemmed Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts – Crucial ‘Human Osteoclastology’
title_short Effects of NSAIDs on Differentiation and Function of Human and Murine Osteoclasts – Crucial ‘Human Osteoclastology’
title_sort effects of nsaids on differentiation and function of human and murine osteoclasts – crucial ‘human osteoclastology’
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033988/
https://www.ncbi.nlm.nih.gov/pubmed/27713309
http://dx.doi.org/10.3390/ph3051394
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