Acid-Sensing Ion Channels and Pain

Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence su...

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Detalles Bibliográficos
Autores principales: Gu, Qihai, Lee, Lu-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033989/
https://www.ncbi.nlm.nih.gov/pubmed/27713310
http://dx.doi.org/10.3390/ph3051411
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author Gu, Qihai
Lee, Lu-Yuan
author_facet Gu, Qihai
Lee, Lu-Yuan
author_sort Gu, Qihai
collection PubMed
description Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management.
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spelling pubmed-40339892014-05-27 Acid-Sensing Ion Channels and Pain Gu, Qihai Lee, Lu-Yuan Pharmaceuticals (Basel) Review Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management. MDPI 2010-05-11 /pmc/articles/PMC4033989/ /pubmed/27713310 http://dx.doi.org/10.3390/ph3051411 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Gu, Qihai
Lee, Lu-Yuan
Acid-Sensing Ion Channels and Pain
title Acid-Sensing Ion Channels and Pain
title_full Acid-Sensing Ion Channels and Pain
title_fullStr Acid-Sensing Ion Channels and Pain
title_full_unstemmed Acid-Sensing Ion Channels and Pain
title_short Acid-Sensing Ion Channels and Pain
title_sort acid-sensing ion channels and pain
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033989/
https://www.ncbi.nlm.nih.gov/pubmed/27713310
http://dx.doi.org/10.3390/ph3051411
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