Cargando…

NSAIDs: Old Drugs Reveal New Anticancer Targets

There is compelling evidence that nonsteroidal anti-inflammatory drugs (NSAIDs) and cyclooxygenase-2 selective inhibitors have antineoplastic activity, but toxicity from cyclooxygenase (COX) inhibition and the suppression of physiologically important prostaglandins limits their use for cancer chemop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Piazza, Gary A., Keeton, Adam B., Tinsley, Heather N., Whitt, Jason D., Gary, Bernard D., Mathew, Bini, Singh, Raj, Grizzle, William E., Reynolds, Robert C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034002/ https://www.ncbi.nlm.nih.gov/pubmed/27713322 http://dx.doi.org/10.3390/ph3051652

Ejemplares similares

Novel Non-Cyclooxygenase Inhibitory Derivative of Sulindac Inhibits Breast Cancer Cell Growth In Vitro and Reduces Mammary Tumorigenesis in Rats
por: Tinsley, Heather N., et al.
Publicado: (2023)

Sulindac sulfide selectively increases sensitivity of ABCC1 expressing tumor cells to doxorubicin and glutathione depletion
por: Whitt, Jason D., et al.
Publicado: (2016)

Enhancing anticancer activity of checkpoint immunotherapy by targeting RAS
por: Ward, Antonio B., et al.
Publicado: (2020)

COX-Independent Mechanisms of Cancer Chemoprevention by Anti-Inflammatory Drugs
por: Gurpinar, Evrim, et al.
Publicado: (2013)

β-catenin nuclear translocation in colorectal cancer cells is suppressed by PDE10A inhibition, cGMP elevation, and activation of PKG
por: Lee, Kevin, et al.
Publicado: (2015)

The Role of Cyclic Nucleotide Signaling Pathways in Cancer: Targets for Prevention and Treatment
por: Fajardo, Alexandra M., et al.
Publicado: (2014)

Exploiting RAS Nucleotide Cycling as a Strategy for Drugging RAS-Driven Cancers
por: Mattox, Tyler E., et al.
Publicado: (2019)

Tumor-targeted dual-action NSAID-platinum(iv) anticancer prodrugs
por: Kastner, Alexander, et al.
Publicado: (2023)

Chondrotoxicity of Injectable NSAIDs and Narcotics
por: Abrams, Geoffrey D., et al.
Publicado: (2017)

The path to the clinic: a comprehensive review on direct KRAS(G12C) inhibitors
por: Kwan, Albert K., et al.
Publicado: (2022)

Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review
por: Sohail, Rohab, et al.
Publicado: (2023)

NSAIDs and Cell Proliferation in Colorectal Cancer
por: Ettarh, Raj, et al.
Publicado: (2010)

Antiproliferative activity and possible mechanism of action of certain 5-methoxyindole tethered C-5 functionalized isatins
por: Almutairi, Maha S, et al.
Publicado: (2019)

Caution with NSAIDs
por: Crighton, A., et al.
Publicado: (2020)

First Generation of Antioxidant Precursors for Bioisosteric Se-NSAIDs: Design, Synthesis, and In Vitro and In Vivo Anticancer Evaluation
por: Ramos-Inza, Sandra, et al.
Publicado: (2023)

A series of NSAID-induced anaphylactic response to immunotherapy and a proposal to include NSAIDS avoidance in future immunotherapy guidelines
por: Chen, Jennifer YF, et al.
Publicado: (2014)

Synthesis and preliminary assessment of the anticancer and Wnt/β-catenin inhibitory activity of small amide libraries of fenamates and profens
por: Mathew, Bini, et al.
Publicado: (2017)

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity
por: Li, Nan, et al.
Publicado: (2014)

New Isatin–Indole Conjugates: Synthesis, Characterization, and a Plausible Mechanism of Their in vitro Antiproliferative Activity
por: Al-Wabli, Reem I, et al.
Publicado: (2020)

Editorial: NSAIDs Pharmacogenomics
por: Agúndez, José A. G., et al.
Publicado: (2021)

Current Perspectives in NSAID-Induced Gastropathy
por: Sinha, Mau, et al.
Publicado: (2013)

Enhanced NSAIDs Solubility in Drug–Drug Formulations with Ciprofloxacin †
por: Acebedo-Martínez, Francisco Javier, et al.
Publicado: (2023)

NSAID-Induced Mucosal Injury: Analysis of Gastric Toxicity with New Generation NSAIDs: Ulcerogenicity Compared with Ulcer Healing
por: Halter, Fred, et al.
Publicado: (1997)

New hydrazonoindolin-2-ones: Synthesis, exploration of the possible anti-proliferative mechanism of action and encapsulation into PLGA microspheres
por: Attia, Mohamed I., et al.
Publicado: (2017)

Novel NSAID-Derived Drugs for the Potential Treatment of Alzheimer’s Disease
por: Cacciatore, Ivana, et al.
Publicado: (2016)

Tebrophen — An Old Polyphenol Drug with Anticancer Potential (†)
por: Rubelj, Ivica, et al.
Publicado: (2012)

Phosphodiesterase 10A is overexpressed in lung tumor cells and inhibitors selectively suppress growth by blocking β-catenin and MAPK signaling
por: Zhu, Bing, et al.
Publicado: (2017)

Novel NSAID 1-acyl-4-cycloalkyl/arylsemicarbazides and 1-acyl-5-benzyloxy/hydroxy carbamoylcarbazides as potential anticancer agents and antioxidants
por: Perković, I., et al.
Publicado: (2012)

Cardiorenal Effects of Newer NSAIDs (Celecoxib) versus Classic NSAIDs (Ibuprofen) in Patients with Arthritis
por: Hegazy, Ragia, et al.
Publicado: (2011)

Comparison of CD63 Upregulation Induced by NSAIDs on Basophils and Monocytes in Patients with NSAID Hypersensitivity
por: Abuaf, N., et al.
Publicado: (2012)

Influence of Cyclodextrin Complexation with NSAIDs on NSAID/Cold Stress-Induced Gastric Ulceration in Rats
por: Alsarra, Ibrahim A., et al.
Publicado: (2010)

Pharmacogenomics of NSAID-Induced Upper Gastrointestinal Toxicity
por: McEvoy, L., et al.
Publicado: (2021)

NSAIDs as a Drug Repurposing Strategy for Biofilm Control
por: Leão, Cláudia, et al.
Publicado: (2020)

Drug allergy in children: focus on beta-lactams and NSAIDs
por: Cravidi, Claudio, et al.
Publicado: (2020)

A phototoxic drug reaction due to topical NSAIDs
por: Drivenes, Jakob Lillemoen, et al.
Publicado: (2022)

A knock-out for NSAIDs.
Publicado: (1996)

NSAIDs in orthodontic tooth movement
por: Karthi, Muthukumar, et al.
Publicado: (2012)

Prodrugs of NSAIDs: A Review
por: Shah, Kamal, et al.
Publicado: (2017)

Advances in antitumor effects of NSAIDs
por: Zhang, Zhen, et al.
Publicado: (2018)

NSAID–Gut Microbiota Interactions
por: Maseda, Damian, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qaltkd4sj53dltj90sqos9c2lb