Cargando…

Synthesis and Neuroprotective Action of Optically Pure Neoechinulin A and Its Analogs

We developed an efficient, stereoselective synthetic method for the diketopiperazine moiety of neoechinulin A and its derivatives. The intramolecular cyclization at 80 ºC proceeded with minimal racemization of the stereogenic center at C-12 on neoechinulin A, even though the cyclization at 110 ºC ca...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aoki, Toshiaki, Ohnishi, Kensuke, Kimoto, Masaaki, Fujieda, Satoshi, Kuramochi, Kouji, Takeuchi, Toshifumi, Nakazaki, Atsuo, Watanabe, Nobuo, Sugawara, Fumio, Arai, Takao, Kobayashi, Susumu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034020/ https://www.ncbi.nlm.nih.gov/pubmed/27713287 http://dx.doi.org/10.3390/ph3041063

Ejemplares similares

Synthesis and Antiviral Activities of Neoechinulin B and Its Derivatives
por: Nishiuchi, Kota, et al.
Publicado: (2021)

Therapeutic Potential of Neoechinulins and Their Derivatives: An Overview of the Molecular Mechanisms Behind Pharmacological Activities
por: Sharifi-Rad, Javad, et al.
Publicado: (2021)

A Screening of a Library of T7 Phage-Displayed Peptide Identifies E2F-4 as an Etoposide-Binding Protein
por: Takami, Mihoko, et al.
Publicado: (2011)

Bicarbonate Plays a Critical Role in the Generation of Cytotoxicity during SIN-1 Decomposition in Culture Medium
por: Shirai, Kyo, et al.
Publicado: (2012)

Design, Synthesis, and Biological Evaluation of EdAP, a 4′-Ethynyl-2′-Deoxyadenosine 5′-Monophosphate Analog, as a Potent Influenza a Inhibitor
por: Takeuchi, Toshifumi, et al.
Publicado: (2019)

Neoechinulin A as a Promising SARS-CoV-2 M(pro) Inhibitor: In Vitro and In Silico Study Showing the Ability of Simulations in Discerning Active from Inactive Enzyme Inhibitors
por: Alhadrami, Hani A., et al.
Publicado: (2022)

Identification and Characterization of the Direct Interaction between Methotrexate (MTX) and High-Mobility Group Box 1 (HMGB1) Protein
por: Kuroiwa, Yuki, et al.
Publicado: (2013)

Cyclosporin A Associated Helicase-Like Protein Facilitates the Association of Hepatitis C Virus RNA Polymerase with Its Cellular Cyclophilin B
por: Morohashi, Kengo, et al.
Publicado: (2011)

Effect of Dehydroaltenusin-C12 Derivative, a Selective DNA Polymerase α Inhibitor, on DNA Replication in Cultured Cells
por: Kuriyama, Isoko, et al.
Publicado: (2008)

Cyclosporine Therapy in Patients with Transfusion-independent Non-severe Aplastic Anemia: A Retrospective Analysis
por: Matsuda, Kensuke, et al.
Publicado: (2018)

Anti-Inflammatory Effect of Neoechinulin A from the Marine Fungus Eurotium sp. SF-5989 through the Suppression of NF-кB and p38 MAPK Pathways in Lipopolysaccharide-Stimulated RAW264.7 Macrophages
por: Kim, Kyoung-Su, et al.
Publicado: (2013)

Palladium-Catalyzed Cascade Wacker/Allylation Sequence with Allylic Alcohols Leading to Allylated Dihydropyrones
por: Huang, Wen-Yu, et al.
Publicado: (2017)

Therapeutic Potential of Oridonin and Its Analogs: From Anticancer and Antiinflammation to Neuroprotection
por: Xu, Jimin, et al.
Publicado: (2018)

Antidepressant and Neuroprotective Effects of 3-Hydroxy Paroxetine, an Analog of Paroxetine in Rats
por: Hernández-Arrambide, Pedro Efraín, et al.
Publicado: (2022)

Relationship between Rice Flour Particle Sizes and Expansion Ratio of Pure Rice Bread
por: Murakami, Seigo, et al.
Publicado: (2016)

Isolation, structural determination, and antiviral activities of metabolites from vanitaracin A-producing Talaromyces sp.
por: Kamisuki, Shinji, et al.
Publicado: (2022)

Terazosin Analogs Targeting Pgk1 as Neuroprotective Agents: Design, Synthesis, and Evaluation
por: Wang, Yang, et al.
Publicado: (2022)

Introduction to analog-to-digital converters
por: Waho, Takao
Publicado: (2019)

Is repeated high-dose medroxyprogesterone acetate (MPA) therapy permissible for patients with early stage endometrial cancer or atypical endometrial hyperplasia who desire preserving fertility?
por: Yamagami, Wataru, et al.
Publicado: (2018)

Neuroprotective Potential of Synthetic Mono-Carbonyl Curcumin Analogs Assessed by Molecular Docking Studies
por: Hussain, Haya, et al.
Publicado: (2021)

Mirtazapine exerts astrocyte-mediated dopaminergic neuroprotection
por: Kikuoka, Ryo, et al.
Publicado: (2020)

Pure Laparoscopic Hepatectomy Combined with a Pure Laparoscopic Pringle Maneuver in Patients with Severe Cirrhosis
por: Miyagi, Shigehito, et al.
Publicado: (2015)

Antitumor Activity and Neutrophil‐selective Hematopoietic Toxicity of Busulfan Analogs in Mice
por: Kato, Taketoshi, et al.
Publicado: (1988)

Post-Injury Neuroprotective Effects of the Thalidomide Analog 3,6′-Dithiothalidomide on Traumatic Brain Injury
por: Batsaikhan, Buyandelger, et al.
Publicado: (2019)

GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain
por: Leurs, Ulrike, et al.
Publicado: (2021)

Machine Learning Neuroprotective Strategy Reveals a Unique Set of Parkinson Therapeutic Nicotine Analogs
por: Rojas-Rodríguez, Felipe, et al.
Publicado: (2020)

Aromatic-Turmerone Analogs Protect Dopaminergic Neurons in Midbrain Slice Cultures through Their Neuroprotective Activities
por: Hori, Yuria, et al.
Publicado: (2021)

Design of Tail-Clamp Peptide Nucleic Acid Tethered with Azobenzene Linker for Sequence-Specific Detection of Homopurine DNA
por: Sawada, Shinjiro, et al.
Publicado: (2017)

Cytotoxicity of prostaglandin analog eye drops preserved with benzalkonium chloride in multiple corneoconjunctival cell lines
por: Ayaki, Masahiko, et al.
Publicado: (2010)

Efficacy and Safety of Up to 8 Years of Long-term Growth Hormone Treatment in Short Children Born Small for Gestational Age in Japan: Analysis of the Subpopulation According to the Japanese Guideline
por: Tanaka, Toshiaki, et al.
Publicado: (2012)

S-Nitrosation of Cellular Proteins by NO Donors in Rat Embryonic Fibroblast 3Y1 Cells: Factors Affecting S-Nitrosation
por: Ryuman, Norihiro, et al.
Publicado: (2011)

Pure Air and Pure Blood
por: Work,
Publicado: (1883)

Neuroprotective Effects of Liraglutide for Stroke Model of Rats
por: Sato, Kenichiro, et al.
Publicado: (2013)

Ocular Surface Cytotoxicity and Safety Evaluation of Tafluprost, a Recently Developed Anti-Glaucoma Prostaglandin Analog
por: Niwano, Yoshimi, et al.
Publicado: (2014)

Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase
por: Qian, Li, et al.
Publicado: (2007)

Standardization of Blood Growth Hormone Levels Measured by Different Kits Using a Linear Structural Relationship
por: Saito, Tomohiro, et al.
Publicado: (2006)

3-O-Methylfunicone, a Selective Inhibitor of Mammalian Y-Family DNA Polymerases from an Australian Sea Salt Fungal Strain
por: Mizushina, Yoshiyuki, et al.
Publicado: (2009)

Synthesis and Cytotoxic Evaluation of N-Alkyl-2-halophenazin-1-ones
por: Kohatsu, Haruki, et al.
Publicado: (2020)

Multifocal primary central nervous system angiosarcoma: illustrative case
por: Hirai, Satoshi, et al.
Publicado: (2023)

Anti-VEGF Agents for Ocular Angiogenesis and Vascular Permeability
por: Kimoto, Kenichi, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_hiif86eggdlqjqivhustp27i8t