Cell-Penetrating Fragments of the Cdk5 Regulatory Subunit Are Protective in Models of Neurodegeneration

Cdk5 is essential for neuronal differentiation processes in the brain. Activation of Cdk5 requires the association with the mostly neuron-specific p35 or p39. Overactivation of CDK5 by cleavage of p35 into p25 is thought to be involved in neurodegenerative processes. Here, we have tested an approach...

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Detalles Bibliográficos
Autores principales: Liman, Jan, Weishaupt, Jochen H., Bähr, Mathias, Dietz, Gunnar P.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034031/
https://www.ncbi.nlm.nih.gov/pubmed/27713298
http://dx.doi.org/10.3390/ph3041232

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034031/
https://www.ncbi.nlm.nih.gov/pubmed/27713298
http://dx.doi.org/10.3390/ph3041232

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