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Obesity Drug Update: The Lost Decade?
The growing worldwide obesity epidemic and obesity-related disorders present a huge unmet medical need for safe and effective anti-obesity medications. The discovery of leptin in 1994 was rapidly succeeded by a wave of related discoveries leading to the elaboration of a hypothalamic melanocortinergi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034063/ http://dx.doi.org/10.3390/ph3123494 |
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author | Yao, Fayi MacKenzie, Robert George |
author_facet | Yao, Fayi MacKenzie, Robert George |
author_sort | Yao, Fayi |
collection | PubMed |
description | The growing worldwide obesity epidemic and obesity-related disorders present a huge unmet medical need for safe and effective anti-obesity medications. The discovery of leptin in 1994 was rapidly succeeded by a wave of related discoveries leading to the elaboration of a hypothalamic melanocortinergic neuronal circuit regulated by leptin and other central and peripheral signaling molecules to control energy homeostasis. The identification of specific neuronal subtypes along with their unique connections and expression products generated a rich target menu for anti-obesity drug discovery programs. Over the course of the last decade, several new chemical entities aimed at these targets have reached various stages or successfully completed the drug discovery/regulatory process only to be dropped or taken off the market. There are now in fact fewer options for anti-obesity drug therapies in late 2010 than were available in 2000. The challenge to discover safe and effective anti-obesity drugs is alive and well. |
format | Online Article Text |
id | pubmed-4034063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40340632014-05-27 Obesity Drug Update: The Lost Decade? Yao, Fayi MacKenzie, Robert George Pharmaceuticals (Basel) Review The growing worldwide obesity epidemic and obesity-related disorders present a huge unmet medical need for safe and effective anti-obesity medications. The discovery of leptin in 1994 was rapidly succeeded by a wave of related discoveries leading to the elaboration of a hypothalamic melanocortinergic neuronal circuit regulated by leptin and other central and peripheral signaling molecules to control energy homeostasis. The identification of specific neuronal subtypes along with their unique connections and expression products generated a rich target menu for anti-obesity drug discovery programs. Over the course of the last decade, several new chemical entities aimed at these targets have reached various stages or successfully completed the drug discovery/regulatory process only to be dropped or taken off the market. There are now in fact fewer options for anti-obesity drug therapies in late 2010 than were available in 2000. The challenge to discover safe and effective anti-obesity drugs is alive and well. MDPI 2010-11-24 /pmc/articles/PMC4034063/ http://dx.doi.org/10.3390/ph3123494 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Yao, Fayi MacKenzie, Robert George Obesity Drug Update: The Lost Decade? |
title | Obesity Drug Update: The Lost Decade? |
title_full | Obesity Drug Update: The Lost Decade? |
title_fullStr | Obesity Drug Update: The Lost Decade? |
title_full_unstemmed | Obesity Drug Update: The Lost Decade? |
title_short | Obesity Drug Update: The Lost Decade? |
title_sort | obesity drug update: the lost decade? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034063/ http://dx.doi.org/10.3390/ph3123494 |
work_keys_str_mv | AT yaofayi obesitydrugupdatethelostdecade AT mackenzierobertgeorge obesitydrugupdatethelostdecade |