Inactivation of Anandamide Signaling: A Continuing Debate

Since the first endocannabinoid anandamide was identified in 1992, extensive research has been conducted to characterize the elements of the tightly controlled endocannabinoid signaling system. While it was established that the activity of endocannabinoids are terminated by a two-step process that i...

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Detalles Bibliográficos
Autores principales: Khairy, Hesham, Houssen, Wael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034072/
http://dx.doi.org/10.3390/ph3113355
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author Khairy, Hesham
Houssen, Wael E.
author_facet Khairy, Hesham
Houssen, Wael E.
author_sort Khairy, Hesham
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description Since the first endocannabinoid anandamide was identified in 1992, extensive research has been conducted to characterize the elements of the tightly controlled endocannabinoid signaling system. While it was established that the activity of endocannabinoids are terminated by a two-step process that includes cellular uptake and degradation, there is still a continuing debate about the mechanistic role of these processes in inactivating anandamide signals.
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spelling pubmed-40340722014-05-27 Inactivation of Anandamide Signaling: A Continuing Debate Khairy, Hesham Houssen, Wael E. Pharmaceuticals (Basel) Review Since the first endocannabinoid anandamide was identified in 1992, extensive research has been conducted to characterize the elements of the tightly controlled endocannabinoid signaling system. While it was established that the activity of endocannabinoids are terminated by a two-step process that includes cellular uptake and degradation, there is still a continuing debate about the mechanistic role of these processes in inactivating anandamide signals. MDPI 2010-10-28 /pmc/articles/PMC4034072/ http://dx.doi.org/10.3390/ph3113355 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Khairy, Hesham
Houssen, Wael E.
Inactivation of Anandamide Signaling: A Continuing Debate
title Inactivation of Anandamide Signaling: A Continuing Debate
title_full Inactivation of Anandamide Signaling: A Continuing Debate
title_fullStr Inactivation of Anandamide Signaling: A Continuing Debate
title_full_unstemmed Inactivation of Anandamide Signaling: A Continuing Debate
title_short Inactivation of Anandamide Signaling: A Continuing Debate
title_sort inactivation of anandamide signaling: a continuing debate
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034072/
http://dx.doi.org/10.3390/ph3113355
work_keys_str_mv AT khairyhesham inactivationofanandamidesignalingacontinuingdebate
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