Effect of Lacto-N-biose I on the Antigen-specific Immune Responses of Splenocytes

We examined the effect of lacto-N-biose I (LNB) on Antigen (Ag)-specific responses of immune cells. LNB exposure in vitro suppressed Ag-specific Interleukin (IL)-4 secretion of mouse splenocytes significantly. However, IL-4 secretion from CD4(+) T cells stimulated with anti-CD3ε did not changed sign...

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Detalles Bibliográficos
Autores principales: GOTO, Masao, TAKANO-ISHIKAWA, Yuko, NISHIMOTO, Mamoru, KITAOKA, Motomitsu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscience of Microbiota, Food and Health 2012
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034288/
https://www.ncbi.nlm.nih.gov/pubmed/24936348
http://dx.doi.org/10.12938/bmfh.31.47
Descripción
Sumario:We examined the effect of lacto-N-biose I (LNB) on Antigen (Ag)-specific responses of immune cells. LNB exposure in vitro suppressed Ag-specific Interleukin (IL)-4 secretion of mouse splenocytes significantly. However, IL-4 secretion from CD4(+) T cells stimulated with anti-CD3ε did not changed significantly with LNB exposure. Additionally, Ag-specific Th1 cytokines did not change. Therefore LNB might suppress Ag-specific IL-4 through modification of Ag-presenting cells (APCs) in a manner independent of Th1-type immune development.

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