Cargando…

Local drug delivery agents as adjuncts to endodontic and periodontal therapy

Abstract In the treatment of intracanal and periodontal infections, the local application of antibiotics and other therapeutic agents in the root canal or in periodontal pockets may be a promising approach to achieve sustained/controlled drug release, high antimicrobial activity and low systemic sid...

Descripción completa

Detalles Bibliográficos
Autores principales: Puri, K, Puri, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Carol Davila University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034307/
https://www.ncbi.nlm.nih.gov/pubmed/24868252
_version_ 1782317946882752512
author Puri, K
Puri, N
author_facet Puri, K
Puri, N
author_sort Puri, K
collection PubMed
description Abstract In the treatment of intracanal and periodontal infections, the local application of antibiotics and other therapeutic agents in the root canal or in periodontal pockets may be a promising approach to achieve sustained/controlled drug release, high antimicrobial activity and low systemic side effects. The conventional method for the elimination of subgingival microbial infection includes mechanical debridement, irrigation with antimicrobial agents or surgical access. But, the effectiveness of conventional nonsurgical treatment is limited by lack of accessibility to bacteria in deeper periodontal pockets, and/or does not completely eliminate intracanal microorganisms. Surgical intervention may be beneficial but cannot be done in all cases, medically compromised cases and also in patients not willing to be subjected to surgical therapy. Development of local drug delivery systems provides an answer to all such difficulties. This comprehensive review tries to cover the detailed information about the latest advances in the various local drug delivery systems, their indications, contraindications and their advantages over systemic drug therapy.
format Online
Article
Text
id pubmed-4034307
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Carol Davila University Press
record_format MEDLINE/PubMed
spelling pubmed-40343072014-05-27 Local drug delivery agents as adjuncts to endodontic and periodontal therapy Puri, K Puri, N J Med Life General Article Abstract In the treatment of intracanal and periodontal infections, the local application of antibiotics and other therapeutic agents in the root canal or in periodontal pockets may be a promising approach to achieve sustained/controlled drug release, high antimicrobial activity and low systemic side effects. The conventional method for the elimination of subgingival microbial infection includes mechanical debridement, irrigation with antimicrobial agents or surgical access. But, the effectiveness of conventional nonsurgical treatment is limited by lack of accessibility to bacteria in deeper periodontal pockets, and/or does not completely eliminate intracanal microorganisms. Surgical intervention may be beneficial but cannot be done in all cases, medically compromised cases and also in patients not willing to be subjected to surgical therapy. Development of local drug delivery systems provides an answer to all such difficulties. This comprehensive review tries to cover the detailed information about the latest advances in the various local drug delivery systems, their indications, contraindications and their advantages over systemic drug therapy. Carol Davila University Press 2013-12-15 2013-12-25 /pmc/articles/PMC4034307/ /pubmed/24868252 Text en ©Carol Davila University Press http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle General Article
Puri, K
Puri, N
Local drug delivery agents as adjuncts to endodontic and periodontal therapy
title Local drug delivery agents as adjuncts to endodontic and periodontal therapy
title_full Local drug delivery agents as adjuncts to endodontic and periodontal therapy
title_fullStr Local drug delivery agents as adjuncts to endodontic and periodontal therapy
title_full_unstemmed Local drug delivery agents as adjuncts to endodontic and periodontal therapy
title_short Local drug delivery agents as adjuncts to endodontic and periodontal therapy
title_sort local drug delivery agents as adjuncts to endodontic and periodontal therapy
topic General Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034307/
https://www.ncbi.nlm.nih.gov/pubmed/24868252
work_keys_str_mv AT purik localdrugdeliveryagentsasadjunctstoendodonticandperiodontaltherapy
AT purin localdrugdeliveryagentsasadjunctstoendodonticandperiodontaltherapy