Food Allergen-induced IgE Response Mouse Model Created by Injection of in vitro Differentiated Th2 Cell Culture and Oral Antigen Intake

Immunoglobulin (Ig) E is a mediator of food allergic reaction; however, the mechanisms of its production in response to an ingested antigen are not fully understood. For analysis of IgE production, here we propose an IgE response mouse model created by injection of a Th2 cell culture and feeding of...

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Autores principales: SHIBAHARA, Kyoko, NAKAJIMA-ADACHI, Haruyo, KAMINUMA, Osamu, HIROI, Takachika, MORI, Akio, HACHIMURA, Satoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscience of Microbiota, Food and Health 2014
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034324/
https://www.ncbi.nlm.nih.gov/pubmed/24936381
http://dx.doi.org/10.12938/bmfh.33.41
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author SHIBAHARA, Kyoko
NAKAJIMA-ADACHI, Haruyo
KAMINUMA, Osamu
HIROI, Takachika
MORI, Akio
HACHIMURA, Satoshi
author_facet SHIBAHARA, Kyoko
NAKAJIMA-ADACHI, Haruyo
KAMINUMA, Osamu
HIROI, Takachika
MORI, Akio
HACHIMURA, Satoshi
author_sort SHIBAHARA, Kyoko
collection PubMed
description Immunoglobulin (Ig) E is a mediator of food allergic reaction; however, the mechanisms of its production in response to an ingested antigen are not fully understood. For analysis of IgE production, here we propose an IgE response mouse model created by injection of a Th2 cell culture and feeding of an egg white diet. According to this manipulation, total and ovalbumin specific IgE production were elevated in this model. We think our model enables us to analyze IgE induction by Th2 cells in food allergy and can contribute to the development of a treatment for food allergy.
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spelling pubmed-40343242014-06-16 Food Allergen-induced IgE Response Mouse Model Created by Injection of in vitro Differentiated Th2 Cell Culture and Oral Antigen Intake SHIBAHARA, Kyoko NAKAJIMA-ADACHI, Haruyo KAMINUMA, Osamu HIROI, Takachika MORI, Akio HACHIMURA, Satoshi Biosci Microbiota Food Health Note Immunoglobulin (Ig) E is a mediator of food allergic reaction; however, the mechanisms of its production in response to an ingested antigen are not fully understood. For analysis of IgE production, here we propose an IgE response mouse model created by injection of a Th2 cell culture and feeding of an egg white diet. According to this manipulation, total and ovalbumin specific IgE production were elevated in this model. We think our model enables us to analyze IgE induction by Th2 cells in food allergy and can contribute to the development of a treatment for food allergy. Bioscience of Microbiota, Food and Health 2014-01-30 2014 /pmc/articles/PMC4034324/ /pubmed/24936381 http://dx.doi.org/10.12938/bmfh.33.41 Text en Bioscience of Microbiota, Food and Health http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Note
SHIBAHARA, Kyoko
NAKAJIMA-ADACHI, Haruyo
KAMINUMA, Osamu
HIROI, Takachika
MORI, Akio
HACHIMURA, Satoshi
Food Allergen-induced IgE Response Mouse Model Created by Injection of in vitro Differentiated Th2 Cell Culture and Oral Antigen Intake
title Food Allergen-induced IgE Response Mouse Model Created by Injection of in vitro Differentiated Th2 Cell Culture and Oral Antigen Intake
title_full Food Allergen-induced IgE Response Mouse Model Created by Injection of in vitro Differentiated Th2 Cell Culture and Oral Antigen Intake
title_fullStr Food Allergen-induced IgE Response Mouse Model Created by Injection of in vitro Differentiated Th2 Cell Culture and Oral Antigen Intake
title_full_unstemmed Food Allergen-induced IgE Response Mouse Model Created by Injection of in vitro Differentiated Th2 Cell Culture and Oral Antigen Intake
title_short Food Allergen-induced IgE Response Mouse Model Created by Injection of in vitro Differentiated Th2 Cell Culture and Oral Antigen Intake
title_sort food allergen-induced ige response mouse model created by injection of in vitro differentiated th2 cell culture and oral antigen intake
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034324/
https://www.ncbi.nlm.nih.gov/pubmed/24936381
http://dx.doi.org/10.12938/bmfh.33.41
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