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Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice

Some anti-inflammatory medications reduce alcohol consumption in rodent models. Inhibition of phosphodiesterases (PDE) increases cAMP and reduces inflammatory signaling. Rolipram, an inhibitor of PDE4, markedly reduced ethanol intake and preference in mice and reduced ethanol seeking and consumption...

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Detalles Bibliográficos
Autores principales:	Blednov, Yuri A., Benavidez, Jillian M., Black, Mendy, Harris, R. Adron
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034339/ https://www.ncbi.nlm.nih.gov/pubmed/24904269 http://dx.doi.org/10.3389/fnins.2014.00129

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