Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure—a suggested HPNS partial mechanism

Professional deep sea divers experience motor and cognitive impairment, known as High Pressure Neurological Syndrome (HPNS), when exposed to pressures of 100 msw (1.1 MPa) and above, considered to be the result of synaptic transmission alteration. Previous studies have indicated modulation of presyn...

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Detalles Bibliográficos
Autores principales: Aviner, Ben, Gradwohl, Gideon, Mor Aviner, Merav, Levy, Shiri, Grossman, Yoram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034351/
https://www.ncbi.nlm.nih.gov/pubmed/24904281
http://dx.doi.org/10.3389/fncel.2014.00136
Descripción
Sumario:Professional deep sea divers experience motor and cognitive impairment, known as High Pressure Neurological Syndrome (HPNS), when exposed to pressures of 100 msw (1.1 MPa) and above, considered to be the result of synaptic transmission alteration. Previous studies have indicated modulation of presynaptic Ca(2+) currents at high pressure. We directly measured for the first time pressure effects on the currents of voltage dependent Ca(2+) channels (VDCCs) expressed in Xenopus oocytes. Pressure selectivity augmented the current in Ca(V)1.2 and depressed it in Ca(V)3.2 channels. Pressure application also affected the channels' kinetics, such as Ʈ(Rise), Ʈ(Decay). Pressure modulation of VDCCs seems to play an important role in generation of HPNS signs and symptoms.

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