Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure—a suggested HPNS partial mechanism

Professional deep sea divers experience motor and cognitive impairment, known as High Pressure Neurological Syndrome (HPNS), when exposed to pressures of 100 msw (1.1 MPa) and above, considered to be the result of synaptic transmission alteration. Previous studies have indicated modulation of presyn...

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Autores principales: Aviner, Ben, Gradwohl, Gideon, Mor Aviner, Merav, Levy, Shiri, Grossman, Yoram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034351/
https://www.ncbi.nlm.nih.gov/pubmed/24904281
http://dx.doi.org/10.3389/fncel.2014.00136
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author Aviner, Ben
Gradwohl, Gideon
Mor Aviner, Merav
Levy, Shiri
Grossman, Yoram
author_facet Aviner, Ben
Gradwohl, Gideon
Mor Aviner, Merav
Levy, Shiri
Grossman, Yoram
author_sort Aviner, Ben
collection PubMed
description Professional deep sea divers experience motor and cognitive impairment, known as High Pressure Neurological Syndrome (HPNS), when exposed to pressures of 100 msw (1.1 MPa) and above, considered to be the result of synaptic transmission alteration. Previous studies have indicated modulation of presynaptic Ca(2+) currents at high pressure. We directly measured for the first time pressure effects on the currents of voltage dependent Ca(2+) channels (VDCCs) expressed in Xenopus oocytes. Pressure selectivity augmented the current in Ca(V)1.2 and depressed it in Ca(V)3.2 channels. Pressure application also affected the channels' kinetics, such as Ʈ(Rise), Ʈ(Decay). Pressure modulation of VDCCs seems to play an important role in generation of HPNS signs and symptoms.
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spelling pubmed-40343512014-06-05 Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure—a suggested HPNS partial mechanism Aviner, Ben Gradwohl, Gideon Mor Aviner, Merav Levy, Shiri Grossman, Yoram Front Cell Neurosci Neuroscience Professional deep sea divers experience motor and cognitive impairment, known as High Pressure Neurological Syndrome (HPNS), when exposed to pressures of 100 msw (1.1 MPa) and above, considered to be the result of synaptic transmission alteration. Previous studies have indicated modulation of presynaptic Ca(2+) currents at high pressure. We directly measured for the first time pressure effects on the currents of voltage dependent Ca(2+) channels (VDCCs) expressed in Xenopus oocytes. Pressure selectivity augmented the current in Ca(V)1.2 and depressed it in Ca(V)3.2 channels. Pressure application also affected the channels' kinetics, such as Ʈ(Rise), Ʈ(Decay). Pressure modulation of VDCCs seems to play an important role in generation of HPNS signs and symptoms. Frontiers Media S.A. 2014-05-27 /pmc/articles/PMC4034351/ /pubmed/24904281 http://dx.doi.org/10.3389/fncel.2014.00136 Text en Copyright © 2014 Aviner, Gradwohl, Mor Aviner, Levy and Grossman. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Aviner, Ben
Gradwohl, Gideon
Mor Aviner, Merav
Levy, Shiri
Grossman, Yoram
Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure—a suggested HPNS partial mechanism
title Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure—a suggested HPNS partial mechanism
title_full Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure—a suggested HPNS partial mechanism
title_fullStr Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure—a suggested HPNS partial mechanism
title_full_unstemmed Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure—a suggested HPNS partial mechanism
title_short Selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure—a suggested HPNS partial mechanism
title_sort selective modulation of cellular voltage-dependent calcium channels by hyperbaric pressure—a suggested hpns partial mechanism
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034351/
https://www.ncbi.nlm.nih.gov/pubmed/24904281
http://dx.doi.org/10.3389/fncel.2014.00136
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