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KK/Ta Mice Administered Lactobacillus plantarum Strain No. 14 Have Lower Adiposity and Higher Insulin Sensitivity
Excess accumulation of white adipose tissue can lead to obesity-related metabolic abnormalities such as insulin resistance. We previously reported that intragastric administration of Lactobacillus plantarum No. 14 reduced adipocyte size in diet-induced obese C57BL/6 mice. The present study tested wh...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Bioscience of Microbiota, Food and Health
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034365/ https://www.ncbi.nlm.nih.gov/pubmed/24936367 http://dx.doi.org/10.12938/bmfh.32.93 |
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author | OKUBO, Takuma TAKEMURA, Naoki YOSHIDA, Ayako SONOYAMA, Kei |
author_facet | OKUBO, Takuma TAKEMURA, Naoki YOSHIDA, Ayako SONOYAMA, Kei |
author_sort | OKUBO, Takuma |
collection | PubMed |
description | Excess accumulation of white adipose tissue can lead to obesity-related metabolic abnormalities such as insulin resistance. We previously reported that intragastric administration of Lactobacillus plantarum No. 14 reduced adipocyte size in diet-induced obese C57BL/6 mice. The present study tested whether L. plantarum No. 14 affects adiposity and insulin sensitivity in an animal model of type-2 diabetes mellitus. Male KK/Ta mice were fed a normal-fat diet and intragastrically given L. plantarum No. 14 (10(8) CFU/mouse) or vehicle daily for 10 weeks. Interscapular brown adipose tissue and inguinal, mesenteric, and retroperitoneal white adipose tissue weights, serum leptin and insulin concentrations, and insulin resistance index (HOMA-IR) were significantly lower in L. plantarum No. 14-fed mice than in vehicle-fed mice. The sum of the inguinal, epididymal, mesenteric and retroperitoneal white adipose tissue weights correlated with serum leptin and non-esterified fatty acid concentrations and HOMA-IR. The mesenteric adipose tissue mRNA levels of monocyte chemoattractant protein-1 and tumor necrosis factor-α were significantly lower in L. plantarum No. 14-fed mice than in vehicle-fed mice. Mesenteric adipose tissue weight correlated with interleukin-6, monocyte chemoattractant protein-1, and tumor necrosis factor-α mRNA levels. HOMA-IR correlated with monocyte chemoattractant protein-1 and tumor necrosis factor-α mRNA levels. These data suggest that L. plantarum No. 14 prevents the development of insulin resistance, which is at least partly attributable to the prevention of obesity, in KK/Ta mice. |
format | Online Article Text |
id | pubmed-4034365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Bioscience of Microbiota, Food and Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-40343652014-06-16 KK/Ta Mice Administered Lactobacillus plantarum Strain No. 14 Have Lower Adiposity and Higher Insulin Sensitivity OKUBO, Takuma TAKEMURA, Naoki YOSHIDA, Ayako SONOYAMA, Kei Biosci Microbiota Food Health Full Paper Excess accumulation of white adipose tissue can lead to obesity-related metabolic abnormalities such as insulin resistance. We previously reported that intragastric administration of Lactobacillus plantarum No. 14 reduced adipocyte size in diet-induced obese C57BL/6 mice. The present study tested whether L. plantarum No. 14 affects adiposity and insulin sensitivity in an animal model of type-2 diabetes mellitus. Male KK/Ta mice were fed a normal-fat diet and intragastrically given L. plantarum No. 14 (10(8) CFU/mouse) or vehicle daily for 10 weeks. Interscapular brown adipose tissue and inguinal, mesenteric, and retroperitoneal white adipose tissue weights, serum leptin and insulin concentrations, and insulin resistance index (HOMA-IR) were significantly lower in L. plantarum No. 14-fed mice than in vehicle-fed mice. The sum of the inguinal, epididymal, mesenteric and retroperitoneal white adipose tissue weights correlated with serum leptin and non-esterified fatty acid concentrations and HOMA-IR. The mesenteric adipose tissue mRNA levels of monocyte chemoattractant protein-1 and tumor necrosis factor-α were significantly lower in L. plantarum No. 14-fed mice than in vehicle-fed mice. Mesenteric adipose tissue weight correlated with interleukin-6, monocyte chemoattractant protein-1, and tumor necrosis factor-α mRNA levels. HOMA-IR correlated with monocyte chemoattractant protein-1 and tumor necrosis factor-α mRNA levels. These data suggest that L. plantarum No. 14 prevents the development of insulin resistance, which is at least partly attributable to the prevention of obesity, in KK/Ta mice. Bioscience of Microbiota, Food and Health 2013-07-25 2013 /pmc/articles/PMC4034365/ /pubmed/24936367 http://dx.doi.org/10.12938/bmfh.32.93 Text en Bioscience of Microbiota, Food and Health http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Full Paper OKUBO, Takuma TAKEMURA, Naoki YOSHIDA, Ayako SONOYAMA, Kei KK/Ta Mice Administered Lactobacillus plantarum Strain No. 14 Have Lower Adiposity and Higher Insulin Sensitivity |
title | KK/Ta Mice Administered Lactobacillus plantarum Strain No.
14 Have Lower Adiposity and Higher Insulin Sensitivity |
title_full | KK/Ta Mice Administered Lactobacillus plantarum Strain No.
14 Have Lower Adiposity and Higher Insulin Sensitivity |
title_fullStr | KK/Ta Mice Administered Lactobacillus plantarum Strain No.
14 Have Lower Adiposity and Higher Insulin Sensitivity |
title_full_unstemmed | KK/Ta Mice Administered Lactobacillus plantarum Strain No.
14 Have Lower Adiposity and Higher Insulin Sensitivity |
title_short | KK/Ta Mice Administered Lactobacillus plantarum Strain No.
14 Have Lower Adiposity and Higher Insulin Sensitivity |
title_sort | kk/ta mice administered lactobacillus plantarum strain no.
14 have lower adiposity and higher insulin sensitivity |
topic | Full Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034365/ https://www.ncbi.nlm.nih.gov/pubmed/24936367 http://dx.doi.org/10.12938/bmfh.32.93 |
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