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No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature
Vitamin D deficiency is associated with a number of human disorders, including cardiovascular disease, cancer, diabetes, frailty, and infections. Since an association between vitamin D and migraine has also been recently speculated, we performed an electronic search on Medline, Scopus, and Web of Sc...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034395/ https://www.ncbi.nlm.nih.gov/pubmed/24900990 http://dx.doi.org/10.1155/2014/827635 |
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author | Lippi, Giuseppe Cervellin, Gianfranco Mattiuzzi, Camilla |
author_facet | Lippi, Giuseppe Cervellin, Gianfranco Mattiuzzi, Camilla |
author_sort | Lippi, Giuseppe |
collection | PubMed |
description | Vitamin D deficiency is associated with a number of human disorders, including cardiovascular disease, cancer, diabetes, frailty, and infections. Since an association between vitamin D and migraine has also been recently speculated, we performed an electronic search on Medline, Scopus, and Web of Science using the keywords “migraine” and “vitamin D,” “25OH-D” “cholecalciferol,” “ergocalciferol,” with no language or date restriction. The electronic search allowed identifying seven studies (3 observational, 2 cross-sectional, and 2 case reports). The two case reports, including four women, showed favourable effects of vitamin D supplementation on migraine severity, but these studies were small and not placebo controlled. As regards the three observational studies, vitamin D deficiency was observed in 13.2 to 14.8% of migraine patients, and these rates do not differ from those reported in the general population (i.e., vitamin D deficiency between 22 and 42%). The results of the two cross-sectional studies are even more controversial, since no association was found between vitamin D status and migraine in both trials. In conclusion, the current evidence suggests that the association between migraine and vitamin D lacks reliable scientific support. |
format | Online Article Text |
id | pubmed-4034395 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40343952014-06-04 No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature Lippi, Giuseppe Cervellin, Gianfranco Mattiuzzi, Camilla Biomed Res Int Review Article Vitamin D deficiency is associated with a number of human disorders, including cardiovascular disease, cancer, diabetes, frailty, and infections. Since an association between vitamin D and migraine has also been recently speculated, we performed an electronic search on Medline, Scopus, and Web of Science using the keywords “migraine” and “vitamin D,” “25OH-D” “cholecalciferol,” “ergocalciferol,” with no language or date restriction. The electronic search allowed identifying seven studies (3 observational, 2 cross-sectional, and 2 case reports). The two case reports, including four women, showed favourable effects of vitamin D supplementation on migraine severity, but these studies were small and not placebo controlled. As regards the three observational studies, vitamin D deficiency was observed in 13.2 to 14.8% of migraine patients, and these rates do not differ from those reported in the general population (i.e., vitamin D deficiency between 22 and 42%). The results of the two cross-sectional studies are even more controversial, since no association was found between vitamin D status and migraine in both trials. In conclusion, the current evidence suggests that the association between migraine and vitamin D lacks reliable scientific support. Hindawi Publishing Corporation 2014 2014-05-08 /pmc/articles/PMC4034395/ /pubmed/24900990 http://dx.doi.org/10.1155/2014/827635 Text en Copyright © 2014 Giuseppe Lippi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lippi, Giuseppe Cervellin, Gianfranco Mattiuzzi, Camilla No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature |
title | No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature |
title_full | No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature |
title_fullStr | No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature |
title_full_unstemmed | No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature |
title_short | No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature |
title_sort | no evidence for an association of vitamin d deficiency and migraine: a systematic review of the literature |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034395/ https://www.ncbi.nlm.nih.gov/pubmed/24900990 http://dx.doi.org/10.1155/2014/827635 |
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