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No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature

Vitamin D deficiency is associated with a number of human disorders, including cardiovascular disease, cancer, diabetes, frailty, and infections. Since an association between vitamin D and migraine has also been recently speculated, we performed an electronic search on Medline, Scopus, and Web of Sc...

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Detalles Bibliográficos
Autores principales: Lippi, Giuseppe, Cervellin, Gianfranco, Mattiuzzi, Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034395/
https://www.ncbi.nlm.nih.gov/pubmed/24900990
http://dx.doi.org/10.1155/2014/827635
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author Lippi, Giuseppe
Cervellin, Gianfranco
Mattiuzzi, Camilla
author_facet Lippi, Giuseppe
Cervellin, Gianfranco
Mattiuzzi, Camilla
author_sort Lippi, Giuseppe
collection PubMed
description Vitamin D deficiency is associated with a number of human disorders, including cardiovascular disease, cancer, diabetes, frailty, and infections. Since an association between vitamin D and migraine has also been recently speculated, we performed an electronic search on Medline, Scopus, and Web of Science using the keywords “migraine” and “vitamin D,” “25OH-D” “cholecalciferol,” “ergocalciferol,” with no language or date restriction. The electronic search allowed identifying seven studies (3 observational, 2 cross-sectional, and 2 case reports). The two case reports, including four women, showed favourable effects of vitamin D supplementation on migraine severity, but these studies were small and not placebo controlled. As regards the three observational studies, vitamin D deficiency was observed in 13.2 to 14.8% of migraine patients, and these rates do not differ from those reported in the general population (i.e., vitamin D deficiency between 22 and 42%). The results of the two cross-sectional studies are even more controversial, since no association was found between vitamin D status and migraine in both trials. In conclusion, the current evidence suggests that the association between migraine and vitamin D lacks reliable scientific support.
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spelling pubmed-40343952014-06-04 No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature Lippi, Giuseppe Cervellin, Gianfranco Mattiuzzi, Camilla Biomed Res Int Review Article Vitamin D deficiency is associated with a number of human disorders, including cardiovascular disease, cancer, diabetes, frailty, and infections. Since an association between vitamin D and migraine has also been recently speculated, we performed an electronic search on Medline, Scopus, and Web of Science using the keywords “migraine” and “vitamin D,” “25OH-D” “cholecalciferol,” “ergocalciferol,” with no language or date restriction. The electronic search allowed identifying seven studies (3 observational, 2 cross-sectional, and 2 case reports). The two case reports, including four women, showed favourable effects of vitamin D supplementation on migraine severity, but these studies were small and not placebo controlled. As regards the three observational studies, vitamin D deficiency was observed in 13.2 to 14.8% of migraine patients, and these rates do not differ from those reported in the general population (i.e., vitamin D deficiency between 22 and 42%). The results of the two cross-sectional studies are even more controversial, since no association was found between vitamin D status and migraine in both trials. In conclusion, the current evidence suggests that the association between migraine and vitamin D lacks reliable scientific support. Hindawi Publishing Corporation 2014 2014-05-08 /pmc/articles/PMC4034395/ /pubmed/24900990 http://dx.doi.org/10.1155/2014/827635 Text en Copyright © 2014 Giuseppe Lippi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lippi, Giuseppe
Cervellin, Gianfranco
Mattiuzzi, Camilla
No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature
title No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature
title_full No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature
title_fullStr No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature
title_full_unstemmed No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature
title_short No Evidence for an Association of Vitamin D Deficiency and Migraine: A Systematic Review of the Literature
title_sort no evidence for an association of vitamin d deficiency and migraine: a systematic review of the literature
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034395/
https://www.ncbi.nlm.nih.gov/pubmed/24900990
http://dx.doi.org/10.1155/2014/827635
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