Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis

Among the symptoms of patients with rheumatoid arthritis (RA), joint stiffness is influenced by diurnal rhythm and reaches peak in the morning, which is a common complaint and reflects the circadian nature of disease manifestation. In addition, inflammatory cytokines, which reach peak secretion earl...

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Detalles Bibliográficos
Autores principales: Yoshida, Kohsuke, Hashimoto, Teppei, Sakai, Yoshitada, Hashiramoto, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034483/
https://www.ncbi.nlm.nih.gov/pubmed/24901009
http://dx.doi.org/10.1155/2014/282495
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author Yoshida, Kohsuke
Hashimoto, Teppei
Sakai, Yoshitada
Hashiramoto, Akira
author_facet Yoshida, Kohsuke
Hashimoto, Teppei
Sakai, Yoshitada
Hashiramoto, Akira
author_sort Yoshida, Kohsuke
collection PubMed
description Among the symptoms of patients with rheumatoid arthritis (RA), joint stiffness is influenced by diurnal rhythm and reaches peak in the morning, which is a common complaint and reflects the circadian nature of disease manifestation. In addition, inflammatory cytokines, which reach peak secretion early in the morning are major players causing the morning stiffness. In this review, we explore the link between the circadian clock and inflammation, focusing on the interactions of various clock genes with the immune-pathways underlying the pathology of rheumatoid arthritis.
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spelling pubmed-40344832014-06-04 Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis Yoshida, Kohsuke Hashimoto, Teppei Sakai, Yoshitada Hashiramoto, Akira J Immunol Res Review Article Among the symptoms of patients with rheumatoid arthritis (RA), joint stiffness is influenced by diurnal rhythm and reaches peak in the morning, which is a common complaint and reflects the circadian nature of disease manifestation. In addition, inflammatory cytokines, which reach peak secretion early in the morning are major players causing the morning stiffness. In this review, we explore the link between the circadian clock and inflammation, focusing on the interactions of various clock genes with the immune-pathways underlying the pathology of rheumatoid arthritis. Hindawi Publishing Corporation 2014 2014-05-08 /pmc/articles/PMC4034483/ /pubmed/24901009 http://dx.doi.org/10.1155/2014/282495 Text en Copyright © 2014 Kohsuke Yoshida et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Yoshida, Kohsuke
Hashimoto, Teppei
Sakai, Yoshitada
Hashiramoto, Akira
Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis
title Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis
title_full Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis
title_fullStr Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis
title_full_unstemmed Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis
title_short Involvement of the Circadian Rhythm and Inflammatory Cytokines in the Pathogenesis of Rheumatoid Arthritis
title_sort involvement of the circadian rhythm and inflammatory cytokines in the pathogenesis of rheumatoid arthritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034483/
https://www.ncbi.nlm.nih.gov/pubmed/24901009
http://dx.doi.org/10.1155/2014/282495
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AT sakaiyoshitada involvementofthecircadianrhythmandinflammatorycytokinesinthepathogenesisofrheumatoidarthritis
AT hashiramotoakira involvementofthecircadianrhythmandinflammatorycytokinesinthepathogenesisofrheumatoidarthritis

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