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Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System

The coating of an active drug, 6-mercaptopurine, into the iron oxide nanoparticles-polyethylene glycol (FNPs-PEG) in order to form a new nanocomposite, FPEGMP-2, was accomplished using coprecipitation technique. The resulting nanosized with a narrow size distribution magnetic polymeric particles sho...

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Autores principales: Dorniani, Dena, Kura, Aminu Umar, Hussein-Al-Ali, Samer Hasan, Hussein, Mohd Zobir bin, Fakurazi, Sharida, Shaari, Abdul Halim, Ahmad, Zalinah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034514/
https://www.ncbi.nlm.nih.gov/pubmed/24895684
http://dx.doi.org/10.1155/2014/972501
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author Dorniani, Dena
Kura, Aminu Umar
Hussein-Al-Ali, Samer Hasan
Hussein, Mohd Zobir bin
Fakurazi, Sharida
Shaari, Abdul Halim
Ahmad, Zalinah
author_facet Dorniani, Dena
Kura, Aminu Umar
Hussein-Al-Ali, Samer Hasan
Hussein, Mohd Zobir bin
Fakurazi, Sharida
Shaari, Abdul Halim
Ahmad, Zalinah
author_sort Dorniani, Dena
collection PubMed
description The coating of an active drug, 6-mercaptopurine, into the iron oxide nanoparticles-polyethylene glycol (FNPs-PEG) in order to form a new nanocomposite, FPEGMP-2, was accomplished using coprecipitation technique. The resulting nanosized with a narrow size distribution magnetic polymeric particles show the superparamagnetic properties with 38.6 emu/g saturation magnetization at room temperature. Fourier transform infrared spectroscopy and the thermal analysis study supported the formation of the nanocomposite and the enhancement of thermal stability in the resulting nanocomposite comparing with its counterpart in free state. The loading of 6-mercaptopurine (MP) in the FPEGMP-2 nanocomposite was estimated to be about 5.6% and the kinetic experimental data properly correlated with the pseudo-second order model. Also, the release of MP from the FPEGMP-2 nanocomposite shows the sustained release manner which is remarkably lower in phosphate buffered solution at pH 7.4 than pH 4.8, due to different release mechanism. The maximum percentage release of MP from the nanocomposite reached about 60% and 97% within about 92 and 74 hours when exposed to pH 7.4 and 4.8, respectively.
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spelling pubmed-40345142014-06-03 Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System Dorniani, Dena Kura, Aminu Umar Hussein-Al-Ali, Samer Hasan Hussein, Mohd Zobir bin Fakurazi, Sharida Shaari, Abdul Halim Ahmad, Zalinah ScientificWorldJournal Research Article The coating of an active drug, 6-mercaptopurine, into the iron oxide nanoparticles-polyethylene glycol (FNPs-PEG) in order to form a new nanocomposite, FPEGMP-2, was accomplished using coprecipitation technique. The resulting nanosized with a narrow size distribution magnetic polymeric particles show the superparamagnetic properties with 38.6 emu/g saturation magnetization at room temperature. Fourier transform infrared spectroscopy and the thermal analysis study supported the formation of the nanocomposite and the enhancement of thermal stability in the resulting nanocomposite comparing with its counterpart in free state. The loading of 6-mercaptopurine (MP) in the FPEGMP-2 nanocomposite was estimated to be about 5.6% and the kinetic experimental data properly correlated with the pseudo-second order model. Also, the release of MP from the FPEGMP-2 nanocomposite shows the sustained release manner which is remarkably lower in phosphate buffered solution at pH 7.4 than pH 4.8, due to different release mechanism. The maximum percentage release of MP from the nanocomposite reached about 60% and 97% within about 92 and 74 hours when exposed to pH 7.4 and 4.8, respectively. Hindawi Publishing Corporation 2014 2014-05-08 /pmc/articles/PMC4034514/ /pubmed/24895684 http://dx.doi.org/10.1155/2014/972501 Text en Copyright © 2014 Dena Dorniani et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dorniani, Dena
Kura, Aminu Umar
Hussein-Al-Ali, Samer Hasan
Hussein, Mohd Zobir bin
Fakurazi, Sharida
Shaari, Abdul Halim
Ahmad, Zalinah
Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System
title Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System
title_full Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System
title_fullStr Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System
title_full_unstemmed Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System
title_short Release Behavior and Toxicity Profiles towards Leukemia (WEHI-3B) Cell Lines of 6-Mercaptopurine-PEG-Coated Magnetite Nanoparticles Delivery System
title_sort release behavior and toxicity profiles towards leukemia (wehi-3b) cell lines of 6-mercaptopurine-peg-coated magnetite nanoparticles delivery system
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034514/
https://www.ncbi.nlm.nih.gov/pubmed/24895684
http://dx.doi.org/10.1155/2014/972501
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