Reversibility of antibiotic resistance

Although theoretically attractive, the reversibility of resistance has proven difficult in practice, even though antibiotic resistance mechanisms induce a fitness cost to the bacterium. Associated resistance to other antibiotics and compensatory mutations seem to ameliorate the effect of antibiotic...

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Detalles Bibliográficos
Autor principal: Sundqvist, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Informa Healthcare 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034551/
https://www.ncbi.nlm.nih.gov/pubmed/24836051
http://dx.doi.org/10.3109/03009734.2014.903323
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author Sundqvist, Martin
author_facet Sundqvist, Martin
author_sort Sundqvist, Martin
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description Although theoretically attractive, the reversibility of resistance has proven difficult in practice, even though antibiotic resistance mechanisms induce a fitness cost to the bacterium. Associated resistance to other antibiotics and compensatory mutations seem to ameliorate the effect of antibiotic interventions in the community. In this paper the current understanding of the concepts of reversibility of antibiotic resistance and the interventions performed in hospitals and in the community are reviewed.
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spelling pubmed-40345512014-06-18 Reversibility of antibiotic resistance Sundqvist, Martin Ups J Med Sci Review Article Although theoretically attractive, the reversibility of resistance has proven difficult in practice, even though antibiotic resistance mechanisms induce a fitness cost to the bacterium. Associated resistance to other antibiotics and compensatory mutations seem to ameliorate the effect of antibiotic interventions in the community. In this paper the current understanding of the concepts of reversibility of antibiotic resistance and the interventions performed in hospitals and in the community are reviewed. Informa Healthcare 2014-05 2014-05-19 /pmc/articles/PMC4034551/ /pubmed/24836051 http://dx.doi.org/10.3109/03009734.2014.903323 Text en © Informa Healthcare http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the CC-BY-NC-ND 3.0 License which permits users to download and share the article for non-commercial purposes, so long as the article is reproduced in the whole without changes, and provided the original source is credited.
spellingShingle Review Article
Sundqvist, Martin
Reversibility of antibiotic resistance
title Reversibility of antibiotic resistance
title_full Reversibility of antibiotic resistance
title_fullStr Reversibility of antibiotic resistance
title_full_unstemmed Reversibility of antibiotic resistance
title_short Reversibility of antibiotic resistance
title_sort reversibility of antibiotic resistance
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034551/
https://www.ncbi.nlm.nih.gov/pubmed/24836051
http://dx.doi.org/10.3109/03009734.2014.903323
work_keys_str_mv AT sundqvistmartin reversibilityofantibioticresistance

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