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Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high rate of mortality and poor prognosis. Numerous studies have proved that microRNA (miRNA) may play a vital role in a wide range of malignancies, including PDAC, and dysregulated miRNAs, including circulating miRNAs, are a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034662/ https://www.ncbi.nlm.nih.gov/pubmed/24899890 http://dx.doi.org/10.1155/2014/386561 |
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author | Sun, Tao Kong, Xiangyu Du, Yiqi Li, Zhaoshen |
author_facet | Sun, Tao Kong, Xiangyu Du, Yiqi Li, Zhaoshen |
author_sort | Sun, Tao |
collection | PubMed |
description | Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high rate of mortality and poor prognosis. Numerous studies have proved that microRNA (miRNA) may play a vital role in a wide range of malignancies, including PDAC, and dysregulated miRNAs, including circulating miRNAs, are associated with PDAC proliferation, invasion, chemosensitivity, and radiosensitivity, as well as prognosis. Greater understanding of the roles of miRNAs in PDAC could provide insights into this disease and identify potential diagnostic markers and therapeutic targets. The current review focuses on recent advances with respect to the roles of miRNAs in PDAC and their practical value. |
format | Online Article Text |
id | pubmed-4034662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40346622014-06-04 Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications Sun, Tao Kong, Xiangyu Du, Yiqi Li, Zhaoshen Gastroenterol Res Pract Review Article Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a high rate of mortality and poor prognosis. Numerous studies have proved that microRNA (miRNA) may play a vital role in a wide range of malignancies, including PDAC, and dysregulated miRNAs, including circulating miRNAs, are associated with PDAC proliferation, invasion, chemosensitivity, and radiosensitivity, as well as prognosis. Greater understanding of the roles of miRNAs in PDAC could provide insights into this disease and identify potential diagnostic markers and therapeutic targets. The current review focuses on recent advances with respect to the roles of miRNAs in PDAC and their practical value. Hindawi Publishing Corporation 2014 2014-05-08 /pmc/articles/PMC4034662/ /pubmed/24899890 http://dx.doi.org/10.1155/2014/386561 Text en Copyright © 2014 Tao Sun et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Sun, Tao Kong, Xiangyu Du, Yiqi Li, Zhaoshen Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications |
title | Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications |
title_full | Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications |
title_fullStr | Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications |
title_full_unstemmed | Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications |
title_short | Aberrant MicroRNAs in Pancreatic Cancer: Researches and Clinical Implications |
title_sort | aberrant micrornas in pancreatic cancer: researches and clinical implications |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034662/ https://www.ncbi.nlm.nih.gov/pubmed/24899890 http://dx.doi.org/10.1155/2014/386561 |
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